Detailed information of TA system TA197438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3179539..3180130
• Replicon: chromosome
• Accession: NZ_CP072162
• Organism: Rhizobium sp. B21/90

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: J5278_RS15410
• Protein ID: WP_209182967.1
• Coordinates: 3179846..3180130 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: J5278_RS15405
• Protein ID: WP_209182968.1
• Coordinates: 3179539..3179835 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5278_RS15390 (J5278_15390)	3174583..3176400	+	1818	WP_209182970.1	methyl-accepting chemotaxis protein	-
J5278_RS15395 (J5278_15395)	3176570..3177166	+	597	WP_142824153.1	histidine phosphatase family protein	-
J5278_RS15400 (J5278_15400)	3177199..3179433	-	2235	WP_219258284.1	glycine--tRNA ligase subunit beta	-
J5278_RS15405 (J5278_15405)	3179539..3179835	-	297	WP_209182968.1	HigA family addiction module antitoxin	Antitoxin
J5278_RS15410 (J5278_15410)	3179846..3180130	-	285	WP_209182967.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J5278_RS15415 (J5278_15415)	3180212..3182155	-	1944	WP_209183018.1	DUF2207 domain-containing protein	-
J5278_RS15420 (J5278_15420)	3182201..3183475	-	1275	WP_209182966.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
J5278_RS15425 (J5278_15425)	3183571..3184122	-	552	WP_209182965.1	LemA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-94)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-92)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10505.98 Da
• Isoelectric Point: 7.2774

>T197438 WP_209182967.1 NZ_CP072162:c3180130-3179846 [Rhizobium sp. B21/90]
MVILSFKDGSTRAVASGVVPKGFPADLARRAIRKLTMIEYANQLSDLRSPPANHLEALKGDRAGQHSIRINDQWRICFVW
TDAGVEDVEIVDYH

Nucleotide

• Length: 285 bp

>T197438 NZ_CP096169:c2916450-2916121 [Shewanella sp. JNE2]
ATGAGTTACACCCCAAAACGAGGTGACATAGTGTGGATTGATTTTGACCCATCTGCGGGACACGAGCAGGCTCATCATCG
TCCTGCGCTGGTACTTTCGCCTGAGCCGTTCAACAAGCAAATTCAACTTGCTTTAGTCGCGCCAATAACATCTAGGGTTA
GAGGTCATGGTTTCGAGGTTGCTGTTGATACCGACAAAACCAAAGGTGTTGTTTTGTGTCAACAAGTCAAGACGATTGAC
TACGCAGCAAGGGACGTCAAGTATATCGAAAAAGCTCCCGTTGCAGTGCTAAATGAAGTGCTCGCAAAAGTGCGAGTATT
GGTCAGTTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11204.13 Da
• Isoelectric Point: 8.6091

>AT197438 WP_209182968.1 NZ_CP072162:c3179835-3179539 [Rhizobium sp. B21/90]
MKHILPPVHPGEILREEYLAPLKMSAGALARKLNVPRTRIERLVAEETPVTIDTALRLARFFDTTPEFWMNMQTGYELKR
QAEEKRAEIAAIPVLHVA

Nucleotide

• Length: 297 bp

>AT197438 NZ_CP096169:c2916704-2916450 [Shewanella sp. JNE2]
ATGCAGACCAGTATCAAAAAATGGGGGAACTCTGCTGGAGCAATTATCCCTGCTGCCGTGCTGAAGAAGGCAGGGTTCGG
TATGGGGGATCAAGTTGAAATAGAGGTTGTTCAGGGGCGTATTGTGATGAGCCCAGCAACCCCAATATTCACACTTGATG
AGTTGCTAAGTGCCAGTCCAAAAGGGTCTTTTGAACTTGATTCAGAAGATACTCAATGGCTGAGTTCGTCACCTGTAGGC
AAGGAAGAAATCTAA