Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2461348..2461865 Replicon chromosome
Accession NZ_CP072116
Organism Staphylococcus aureus strain TCH32929

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag J6L63_RS12230 Protein ID WP_000113265.1
Coordinates 2461599..2461865 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag J6L63_RS12225 Protein ID WP_000584499.1
Coordinates 2461348..2461599 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6L63_RS12195 (2457046) 2457046..2457765 + 720 WP_000479576.1 amino acid ABC transporter permease -
J6L63_RS12200 (2457762) 2457762..2458493 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
J6L63_RS12205 (2458590) 2458590..2459840 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
J6L63_RS12210 (2460095) 2460095..2460457 + 363 WP_000819843.1 DUF4467 domain-containing protein -
J6L63_RS12215 (2460476) 2460476..2461075 + 600 WP_000162810.1 DsbA family protein -
J6L63_RS12220 (2461103) 2461103..2461183 + 81 WP_223197974.1 hypothetical protein -
J6L63_RS12225 (2461348) 2461348..2461599 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J6L63_RS12230 (2461599) 2461599..2461865 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
J6L63_RS12235 (2461900) 2461900..2461971 + 72 Protein_2381 hypothetical protein -
J6L63_RS12240 (2462160) 2462160..2463707 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
J6L63_RS12245 (2463893) 2463893..2464360 + 468 WP_000153347.1 SRPBCC domain-containing protein -
J6L63_RS12250 (2464444) 2464444..2464626 + 183 WP_000230292.1 hypothetical protein -
J6L63_RS12255 (2464843) 2464843..2465667 + 825 WP_000572038.1 formate/nitrite transporter family protein -
J6L63_RS12260 (2465901) 2465901..2466437 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T197318 WP_000113265.1 NZ_CP072116:2461599-2461865 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T197318 NZ_CP096016:c2616136-2615873 [Alkalimarinus coralli]
ATGTATAATTTTGAATTTGACCATAAAAAGAGCAATTCAAATCTAGACAAACATGGTATTGATTTCAATGAGGCTCAGTC
CCTATGGGGTGATCCAGACCTTATAGAAATCCAAGCCAAGTCAGAAGATGAGCCTCGCTCCTTAGTAATAGGCCGTATCG
GTGAAAAACACTGGTCGGCAGTTATTACTTGTCGGAAAGAAAGTATCCGAATAATTTCGGTGAGGCGTTCTCGTAAAACT
GAGGTAGCACTGTATGAAAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT197318 WP_000584499.1 NZ_CP072116:2461348-2461599 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT197318 NZ_CP096016:c2615883-2615632 [Alkalimarinus coralli]
ATGAAAGCTAAAGACTTCGACAAAAAGTTCGATAATAACGAAGATATTATAGATGATCTTGATTTGTCTTCCATTAAGCG
TCCTAACCAAGCTCAGAAAAGAGTAAATGTAGACTTTCCTACTTGGATGATCGATTCCTTAGATAAGGAAGCAAATCGAG
TTGGCGTAACACGCCAATCAATTATCAAAGTCTGGCTAGCGGAGAAGCTGGAAGAACAAGCAGCTAACAAGGCGTTGCAC
CGAACTCGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References