Detailed information of TA system TA197316

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2436141..2436325
• Replicon: chromosome
• Accession: NZ_CP072116
• Organism: Staphylococcus aureus strain TCH32929

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: J6L63_RS12095
• Protein ID: WP_000482652.1
• Coordinates: 2436141..2436248 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2436265..2436325 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6L63_RS12070	2431503..2431976	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
J6L63_RS12075	2432099..2433310	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
J6L63_RS12080	2433492..2434151	-	660	WP_000831298.1	membrane protein	-
J6L63_RS12085	2434211..2435353	-	1143	WP_001176863.1	glycerate kinase	-
J6L63_RS12090	2435621..2436007	+	387	WP_000779360.1	flippase GtxA	-
J6L63_RS12095	2436141..2436248	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2436265..2436325	-	61	-	-	Antitoxin
J6L63_RS12100	2436951..2438714	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
J6L63_RS12105	2438739..2440472	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
J6L63_RS12110	2440739..2440870	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T197316 WP_000482652.1 NZ_CP072116:2436141-2436248 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T197316 NZ_CP096016:c2273558-2273214 [Alkalimarinus coralli]
ATGAAGGCAGTATTTATAGAGTTACCGCCATTTGAGCGGAATAGAGGGCACTATTTAGATGACAATGCTTACCGTAATTT
TCAAAATGAGATACTGAAAAATCCTACATCTGGTGATTTAATAAAAGGGACTTGCGGACTGCGAAAAGTGCGTTATAAGG
ATGAACGTAGACGAAAAGGAAAGCGTGGTGGTGTTAGGGTTATCTACTATTGGTGGAAAGAAGGATCACAGTTTTGGCTT
TTTACCATTTACGACAAAGATGAAGTTACAGACCTTACCAAAGCTGAGCTGAAGTTATTGGCAGACTTGTTGAAGCTTGA
AATTAAAGCGAGAAGCTTATTATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT197316 NZ_CP072116:c2436325-2436265 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin