Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3614076..3614769 Replicon chromosome
Accession NZ_CP072054
Organism Escherichia coli strain K1508

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag J5N95_RS17420 Protein ID WP_000415584.1
Coordinates 3614076..3614372 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J5N95_RS17425 Protein ID WP_000650107.1
Coordinates 3614374..3614769 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5N95_RS17385 (3609164) 3609164..3609478 - 315 WP_000958598.1 putative quinol monooxygenase -
J5N95_RS17390 (3609509) 3609509..3610090 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
J5N95_RS17395 (3610409) 3610409..3610741 + 333 WP_000917684.1 DUF2645 family protein -
J5N95_RS17400 (3610787) 3610787..3612136 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
J5N95_RS17405 (3612133) 3612133..3612792 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
J5N95_RS17410 (3612944) 3612944..3613336 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J5N95_RS17415 (3613389) 3613389..3613871 + 483 WP_000183505.1 GyrI-like domain-containing protein -
J5N95_RS17420 (3614076) 3614076..3614372 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
J5N95_RS17425 (3614374) 3614374..3614769 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J5N95_RS17430 (3614902) 3614902..3616509 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
J5N95_RS17435 (3616647) 3616647..3618905 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T197274 WP_000415584.1 NZ_CP072054:3614076-3614372 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T197274 NZ_CP095856:c4333224-4333006 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT197274 WP_000650107.1 NZ_CP072054:3614374-3614769 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT197274 NZ_CP095856:c4333624-4333250 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References