Detailed information of TA system TA197270

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3081071..3081293
• Replicon: chromosome
• Accession: NZ_CP072054
• Organism: Escherichia coli strain K1508

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: J5N95_RS14835
• Protein ID: WP_000141634.1
• Coordinates: 3081186..3081293 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3081071..3081137 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5N95_RS14815	3076512..3077414	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
J5N95_RS14820	3077425..3078408	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
J5N95_RS14825	3078405..3079409	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
J5N95_RS14830	3079439..3080710	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	3081071..3081137	-	67	-	-	Antitoxin
J5N95_RS14835	3081186..3081293	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
J5N95_RS14840	3081380..3083059	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
J5N95_RS14845	3083056..3083247	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
J5N95_RS14850	3083244..3084815	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
J5N95_RS14855	3085088..3085276	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
J5N95_RS14860	3085312..3086040	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T197270 WP_000141634.1 NZ_CP072054:3081186-3081293 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T197270 NZ_CP095856:c3467806-3467429 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTAGCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT197270 NZ_CP072054:c3081137-3081071 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin