197201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 32004..32523 Replicon plasmid p2VB13828
Accession NZ_CP071960
Organism Enterococcus faecium strain VB13828

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag J4767_RS15110 Protein ID WP_000588503.1
Coordinates 32266..32523 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag J4767_RS15105 Protein ID WP_000388479.1
Coordinates 32004..32273 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4767_RS15070 (J4767_15070) 27581..27997 - 417 WP_208572921.1 hypothetical protein -
J4767_RS15075 (J4767_15075) 27999..28280 - 282 WP_125394241.1 hypothetical protein -
J4767_RS15080 (J4767_15080) 28646..28870 + 225 WP_000410576.1 hypothetical protein -
J4767_RS15090 (J4767_15090) 29991..30671 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
J4767_RS15095 (J4767_15095) 30747..31313 + 567 Protein_36 hypothetical protein -
J4767_RS15640 31478..31678 + 201 WP_001033544.1 4-hydroxybenzoate octaprenyltransferase -
J4767_RS15100 (J4767_15100) 31694..31873 + 180 WP_001120991.1 hypothetical protein -
J4767_RS15105 (J4767_15105) 32004..32273 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4767_RS15110 (J4767_15110) 32266..32523 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
J4767_RS15115 (J4767_15115) 32982..33137 + 156 WP_002347142.1 hypothetical protein -
J4767_RS15120 (J4767_15120) 33161..33769 + 609 WP_224752223.1 hypothetical protein -
J4767_RS15125 (J4767_15125) 33903..35222 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
J4767_RS15130 (J4767_15130) 35435..35668 + 234 WP_002296232.1 hypothetical protein -
J4767_RS15135 (J4767_15135) 35833..36447 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..40984 40984
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..35222 33565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T197201 WP_000588503.1 NZ_CP071960:32266-32523 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T197201 NZ_CP095776:2248022-2248124 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT197201 WP_000388479.1 NZ_CP071960:32004-32273 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT197201 NZ_CP095776:c2248131-2247986 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References