Detailed information of TA system TA197194

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1796973..1797182
• Replicon: chromosome
• Accession: NZ_CP071958
• Organism: Enterococcus faecium strain VB13828

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: J4767_RS15510
• Protein ID: WP_220482000.1
• Coordinates: 1797039..1797182 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1796973..1797059 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4767_RS08815 (J4767_08815)	1792812..1793006	-	195	WP_085811488.1	hypothetical protein	-
J4767_RS08820 (J4767_08820)	1793006..1795570	-	2565	WP_085811487.1	trse protein	-
J4767_RS08825 (J4767_08825)	1795786..1795929	-	144	WP_220481999.1	putative holin-like toxin	-
J4767_RS08830 (J4767_08830)	1796006..1796701	-	696	WP_085811485.1	hypothetical protein	-
-	1796973..1797059	+	87	-	-	Antitoxin
J4767_RS15510	1797039..1797182	-	144	WP_220482000.1	putative holin-like toxin	Toxin
J4767_RS08840 (J4767_08840)	1797262..1797654	-	393	WP_085811484.1	DUF5592 family protein	-
J4767_RS08845 (J4767_08845)	1797666..1799795	-	2130	WP_085811483.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5088.10 Da
• Isoelectric Point: 10.3163

>T197194 WP_220482000.1 NZ_CP071958:c1797182-1797039 [Enterococcus faecium]
MEVSVHSLERRSLLSVAEALGLMISFGSLIATIIFGILTAVKNDKKK

Nucleotide

• Length: 144 bp

>T197194 NZ_CP095774:c2824850-2824272 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAAGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Nucleotide

• Length: 87 bp

>AT197194 NZ_CP071958:1796973-1797059 [Enterococcus faecium]
CCGCTTAAGACGGTGGCGACATTAGTTATATCTAAAAAATAACCGCTGACTCGCTAAAGTAGACGGTTATTTTTTCTTGT
CATTTTT

Structures

Antitoxin