Detailed information of TA system TA197187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4028947..4029537
• Replicon: chromosome
• Accession: NZ_CP071955
• Organism: Xanthomonas fragariae strain YL19

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2N7V9W3
• Locus tag: J5I97_RS19255
• Protein ID: WP_016902142.1
• Coordinates: 4029256..4029537 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: J5I97_RS19250
• Protein ID: WP_002803896.1
• Coordinates: 4028947..4029237 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5I97_RS19235	4026138..4027043	-	906	WP_208588208.1	hypothetical protein	-
J5I97_RS19240	4027106..4027633	-	528	WP_208588209.1	hypothetical protein	-
J5I97_RS19245	4028073..4028405	+	333	WP_208588210.1	hypothetical protein	-
J5I97_RS20245	4028566..4028756	+	191	Protein_3594	hypothetical protein	-
J5I97_RS19250	4028947..4029237	-	291	WP_002803896.1	HigA family addiction module antitoxin	Antitoxin
J5I97_RS19255	4029256..4029537	-	282	WP_016902142.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J5I97_RS19260	4029999..4032134	-	2136	WP_208588211.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-94)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11064.75 Da
• Isoelectric Point: 9.7972

>T197187 WP_016902142.1 NZ_CP071955:c4029537-4029256 [Xanthomonas fragariae]
MIRSFVDKEAEKIWMGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T197187 NZ_CP095770:c6301292-6301014 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10528.25 Da
• Isoelectric Point: 7.1667

>AT197187 WP_002803896.1 NZ_CP071955:c4029237-4028947 [Xanthomonas fragariae]
MTVLPNIHPGEILLEEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALCTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT197187 NZ_CP095770:c6301002-6300697 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: A0A2N7V9W3