197144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 790357..790945 Replicon chromosome
Accession NZ_CP071936
Organism Helicobacter pylori strain MTT03

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag J5F39_RS03840 Protein ID WP_078241888.1
Coordinates 790357..790638 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag J5F39_RS03845 Protein ID WP_078241889.1
Coordinates 790631..790945 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5F39_RS03820 786232..787464 + 1233 WP_283492235.1 ABC transporter permease -
J5F39_RS03825 787744..789243 + 1500 WP_001108245.1 outer membrane beta-barrel protein HofF -
J5F39_RS03830 789593..789760 - 168 Protein_749 restriction endonuclease subunit S -
J5F39_RS03835 789824..790081 + 258 Protein_750 type IV secretory system conjugative DNA transfer family protein -
J5F39_RS03840 790357..790638 - 282 WP_078241888.1 YafQ family addiction module toxin Toxin
J5F39_RS03845 790631..790945 - 315 WP_078241889.1 hypothetical protein Antitoxin
J5F39_RS03850 791143..791289 - 147 Protein_753 restriction endonuclease subunit S -
J5F39_RS03855 791284..791931 + 648 Protein_754 DUF3519 domain-containing protein -
J5F39_RS03860 791933..792476 + 544 Protein_755 hypothetical protein -
J5F39_RS03865 792716..793852 - 1137 WP_283492236.1 potassium channel family protein -
J5F39_RS03870 794034..794222 - 189 WP_001118998.1 50S ribosomal protein L28 -
J5F39_RS03875 794322..795161 - 840 WP_283492237.1 HpaA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10889.83 Da        Isoelectric Point: 9.5726

>T197144 WP_078241888.1 NZ_CP071936:c790638-790357 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDIASIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENEIV
LLRLDTHSELFKK

Download         Length: 282 bp

>T197144 NZ_CP095761:946713-947123 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12178.63 Da        Isoelectric Point: 5.6753

>AT197144 WP_078241889.1 NZ_CP071936:c790945-790631 [Helicobacter pylori]
MSNVITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTQSLLNTINSKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT197144 NZ_CP095761:946466-946732 [Klebsiella michiganensis]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References