Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1001920..1002508 Replicon chromosome
Accession NZ_CP071870
Organism Propioniciclava sp. MC1595

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag J4N02_RS04745 Protein ID WP_101601792.1
Coordinates 1001920..1002201 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4N02_RS04750 Protein ID WP_188332582.1
Coordinates 1002212..1002508 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N02_RS04715 (J4N02_04715) 997112..997369 - 258 WP_188332576.1 WhiB family transcriptional regulator -
J4N02_RS04720 (J4N02_04720) 997366..997653 - 288 WP_188332577.1 AP2 domain-containing protein -
J4N02_RS04725 (J4N02_04725) 997650..999401 - 1752 WP_188332578.1 AAA family ATPase -
J4N02_RS04730 (J4N02_04730) 999398..999799 - 402 WP_188332579.1 hypothetical protein -
J4N02_RS04735 (J4N02_04735) 999955..1000206 - 252 WP_188332580.1 hypothetical protein -
J4N02_RS04740 (J4N02_04740) 1000432..1001820 - 1389 WP_188332581.1 recombinase family protein -
J4N02_RS04745 (J4N02_04745) 1001920..1002201 + 282 WP_101601792.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N02_RS04750 (J4N02_04750) 1002212..1002508 + 297 WP_188332582.1 HigA family addiction module antitoxin Antitoxin
J4N02_RS04755 (J4N02_04755) 1002505..1003329 + 825 WP_188332583.1 SDR family oxidoreductase -
J4N02_RS04760 (J4N02_04760) 1003710..1004417 - 708 WP_188332584.1 DNA methyltransferase -
J4N02_RS04765 (J4N02_04765) 1004451..1004711 - 261 WP_188332585.1 iron-sulfur cluster repair di-iron protein, ric -
J4N02_RS04775 (J4N02_04775) 1005012..1005488 + 477 WP_208091130.1 NlpC/P60 family protein -
J4N02_RS04780 (J4N02_04780) 1005508..1006158 - 651 WP_243760872.1 cation transporter -
J4N02_RS04785 (J4N02_04785) 1006168..1007337 - 1170 WP_182814438.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10822.49 Da        Isoelectric Point: 9.1483

>T197088 WP_101601792.1 NZ_CP071870:1001920-1002201 [Propioniciclava sp. MC1595]
VIVSFADRDAERLFLRQRVKRLDSRLHKKALTKLLLLDAAHELDELRVPPGNRLEALKGDRIGQHSIRINDQWRICFVWT
PAGPSEVEIVDYH

Download         Length: 282 bp

>T197088 NZ_CP095540:3149838-3149940 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11115.91 Da        Isoelectric Point: 5.6786

>AT197088 WP_188332582.1 NZ_CP071870:1002212-1002508 [Propioniciclava sp. MC1595]
MDDKIPPIHPGEILMEEFLVPMGVTQNRLAVSIGVPPRRINEIVHGKRRITADTALRLGRFYSMSAQFWINLQVRYDLEV
EMDALGDALDSIQPLRTA

Download         Length: 297 bp

>AT197088 NZ_CP095540:c3149978-3149710 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References