Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1953282..1953805 Replicon chromosome
Accession NZ_CP071868
Organism Pengzhenrongella sicca strain LRZ-2

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag J4E96_RS08945 Protein ID WP_227425401.1
Coordinates 1953530..1953805 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag J4E96_RS08940 Protein ID WP_227425400.1
Coordinates 1953282..1953533 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4E96_RS08915 (J4E96_08865) 1949003..1949443 + 441 WP_227425397.1 hypothetical protein -
J4E96_RS08920 (J4E96_08870) 1949446..1950126 + 681 WP_227425398.1 response regulator transcription factor -
J4E96_RS08925 (J4E96_08875) 1950123..1951232 + 1110 WP_227425399.1 HAMP domain-containing sensor histidine kinase -
J4E96_RS08930 1951392..1951841 - 450 WP_227425860.1 hypothetical protein -
J4E96_RS08940 (J4E96_08885) 1953282..1953533 + 252 WP_227425400.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J4E96_RS08945 (J4E96_08890) 1953530..1953805 + 276 WP_227425401.1 Txe/YoeB family addiction module toxin Toxin
J4E96_RS08950 (J4E96_08895) 1954015..1954875 - 861 WP_227425402.1 class II fructose-bisphosphate aldolase -
J4E96_RS08955 (J4E96_08900) 1954872..1955822 - 951 WP_227425403.1 ROK family protein -
J4E96_RS08960 (J4E96_08905) 1956044..1957342 + 1299 WP_227425404.1 D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit -
J4E96_RS08965 (J4E96_08910) 1957342..1958535 + 1194 WP_227425405.1 SIS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10800.16 Da        Isoelectric Point: 7.3810

>T197082 WP_227425401.1 NZ_CP071868:1953530-1953805 [Pengzhenrongella sicca]
VRYVWDQDAWSDYVYWQVQDRRVVKRINDLIKDISRGADQATPHEGIGKPEALKHGLHGYWSRRITDEHRLIYKVVDDEI
RIAACCFHYSA

Download         Length: 276 bp

>T197082 NZ_CP095540:1640990-1641304 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9379.48 Da        Isoelectric Point: 4.6657

>AT197082 WP_227425400.1 NZ_CP071868:1953282-1953533 [Pengzhenrongella sicca]
VKTMTYSQSRARYAETLNAVTDDREEVVITRAGHDPVVIVSLADYESLKETAYLLQNPANARRLLTSIERLEAGRGEERE
LVE

Download         Length: 252 bp

>AT197082 NZ_CP095540:1641301-1641717 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References