Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4082054..4082714 Replicon chromosome
Accession NZ_CP071861
Organism Enterobacter cloacae strain GX1Z-1L

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4G41_RS19840 Protein ID WP_167816757.1
Coordinates 4082340..4082714 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4G41_RS19835 Protein ID WP_014832568.1
Coordinates 4082054..4082356 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G41_RS19820 (J4G41_19800) 4079396..4080382 + 987 WP_058683253.1 IS110 family transposase -
J4G41_RS19825 (J4G41_19805) 4080495..4080884 - 390 WP_013097827.1 RidA family protein -
J4G41_RS19830 (J4G41_19810) 4081026..4081958 + 933 WP_058681724.1 LysR family transcriptional regulator -
J4G41_RS19835 (J4G41_19815) 4082054..4082356 - 303 WP_014832568.1 XRE family transcriptional regulator Antitoxin
J4G41_RS19840 (J4G41_19820) 4082340..4082714 - 375 WP_167816757.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G41_RS19845 (J4G41_19825) 4083073..4084023 - 951 WP_047024643.1 HTH-type transcriptional regulator Cbl -
J4G41_RS19850 (J4G41_19830) 4084120..4085037 - 918 WP_010432103.1 nitrogen assimilation transcriptional regulator NAC -
J4G41_RS19860 (J4G41_19840) 4085571..4086467 - 897 WP_167816756.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4079396..4080382 986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14360.35 Da        Isoelectric Point: 9.7082

>T197080 WP_167816757.1 NZ_CP071861:c4082714-4082340 [Enterobacter cloacae]
VWTINTTDRFDCWFRSLDDTDRASVLAALLVLREKGPALSRPYADTLKGSRHSNMKELRIQSKSDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERTLRDGQKP

Download         Length: 375 bp

>T197080 NZ_CP071861:c4082714-4082340 [Enterobacter cloacae]
GTGTGGACAATTAACACGACGGACAGGTTCGATTGCTGGTTTCGTTCACTTGACGATACTGATCGGGCCAGCGTGCTGGC
AGCACTGCTTGTTTTGCGAGAAAAGGGGCCTGCTTTGTCGAGGCCCTATGCCGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTGCGCATTCAGAGTAAGAGCGATCCGTTGCGGGCATTTTTCGCGTTTGACCCAAACCGTACCGGCATT
GTGCTCTGTGCCGGCAATAAGGTCGGCAACGAAAGACGCTTTTACGATGAAATGCTTCTGGTGGCCGACCGGGAATTCAC
TCACTGGTTGAATACATTAAAAGAAAGGACGTTACGCGATGGGCAGAAACCTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10972.69 Da        Isoelectric Point: 5.1473

>AT197080 WP_014832568.1 NZ_CP071861:c4082356-4082054 [Enterobacter cloacae]
MGRNLEQLIADEKSDVVASAQAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLTLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT197080 NZ_CP071861:c4082356-4082054 [Enterobacter cloacae]
ATGGGCAGAAACCTTGAGCAGCTTATAGCGGATGAAAAATCGGATGTTGTTGCCAGCGCTCAGGCAATGGCTGCCGACAT
TTTGCTTAATATCCATCTGGCAGAGCTACGTGAAAAGGTGCAAAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGCATCC
GACAGCCCACCGTCGCGGTCATGGAAAAGCCCGGGCGCGATCTGAAACTCTCTTCACTCAAGCGCTACGTTGAGGCTGCG
GGTGGAAAGCTTACGCTTGACGTTGAGTTACCGGATGGTTCGCATTATGAGTTTGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References