Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1007784..1008417 Replicon chromosome
Accession NZ_CP071849
Organism Vibrio sp. SCSIO 43136

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4N39_RS19445 Protein ID WP_252024003.1
Coordinates 1008085..1008417 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4N39_RS19440 Protein ID WP_252024001.1
Coordinates 1007784..1008098 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N39_RS19395 (J4N39_19405) 1002967..1003308 - 342 WP_252023987.1 DUF4144 domain-containing protein -
J4N39_RS19400 (J4N39_19410) 1003482..1003703 + 222 WP_252023988.1 ParD-like family protein -
J4N39_RS19405 (J4N39_19415) 1003696..1003986 + 291 WP_252023990.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4N39_RS19410 (J4N39_19420) 1004120..1004653 - 534 WP_252023992.1 GNAT family N-acetyltransferase -
J4N39_RS19415 (J4N39_19425) 1004650..1004919 - 270 WP_252023994.1 DUF1778 domain-containing protein -
J4N39_RS19420 (J4N39_19430) 1005153..1005635 - 483 WP_252023995.1 tetratricopeptide repeat protein -
J4N39_RS19425 (J4N39_19435) 1005831..1006115 + 285 WP_252023997.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
J4N39_RS19430 (J4N39_19440) 1006102..1006371 + 270 WP_252023999.1 type II toxin-antitoxin system YafQ family toxin -
J4N39_RS19435 (J4N39_19445) 1006457..1007405 + 949 Protein_903 IS110 family transposase -
J4N39_RS19440 (J4N39_19450) 1007784..1008098 - 315 WP_252024001.1 DNA-binding transcriptional regulator Antitoxin
J4N39_RS19445 (J4N39_19455) 1008085..1008417 - 333 WP_252024003.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N39_RS19450 (J4N39_19460) 1008612..1009229 - 618 WP_252024005.1 LysE family translocator -
J4N39_RS19455 (J4N39_19465) 1009389..1010588 + 1200 WP_252026849.1 IS4 family transposase -
J4N39_RS19460 (J4N39_19470) 1010735..1011658 - 924 WP_252024007.1 hypothetical protein -
J4N39_RS19465 (J4N39_19475) 1012361..1012792 - 432 WP_252026852.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1007028..1007405 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12936.78 Da        Isoelectric Point: 10.0960

>T197047 WP_252024003.1 NZ_CP071849:c1008417-1008085 [Vibrio sp. SCSIO 43136]
MKSVFVESTIFEKYRNEYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKSFMEAWRNEQS

Download         Length: 333 bp

>T197047 NZ_CP095533:4481053-4481430 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11663.12 Da        Isoelectric Point: 6.3290

>AT197047 WP_252024001.1 NZ_CP071849:c1008098-1007784 [Vibrio sp. SCSIO 43136]
MSNRDLFAELSSALVEAKEHSEGKVTLKTHQVSDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT197047 NZ_CP095533:4480595-4480963 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References