Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 56236..56632 Replicon chromosome
Accession NZ_CP071849
Organism Vibrio sp. SCSIO 43136

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4N39_RS15140 Protein ID WP_252025426.1
Coordinates 56507..56632 (-) Length 42 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4N39_RS15135 Protein ID WP_252025423.1
Coordinates 56236..56514 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N39_RS15100 (J4N39_15115) 51560..52555 - 996 WP_252025410.1 permease -
J4N39_RS15105 (J4N39_15120) 52798..53094 + 297 WP_252026898.1 metalloregulator ArsR/SmtB family transcription factor -
J4N39_RS15110 (J4N39_15125) 53129..53488 + 360 WP_252025412.1 MmcQ/YjbR family DNA-binding protein -
J4N39_RS15115 (J4N39_15130) 53557..54399 - 843 WP_252025414.1 siderophore-interacting protein -
J4N39_RS15120 (J4N39_15135) 54399..54902 - 504 WP_252025417.1 DUF2798 domain-containing protein -
J4N39_RS15125 (J4N39_15140) 55003..55434 + 432 WP_252025419.1 MarR family transcriptional regulator -
J4N39_RS15130 (J4N39_15145) 55471..56100 - 630 WP_252025421.1 GyrI-like domain-containing protein -
J4N39_RS15135 (J4N39_15150) 56236..56514 - 279 WP_252025423.1 helix-turn-helix transcriptional regulator Antitoxin
J4N39_RS15140 56507..56632 - 126 WP_252025426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N39_RS15145 56728..56781 - 54 Protein_52 type II toxin-antitoxin system RelE/ParE family toxin -
J4N39_RS15150 57097..57367 - 271 Protein_53 hypothetical protein -
J4N39_RS15155 (J4N39_15165) 57491..58519 - 1029 WP_252025428.1 Abi family protein -
J4N39_RS15160 (J4N39_15170) 58795..60645 - 1851 WP_252026900.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-36)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4891.88 Da        Isoelectric Point: 10.7315

>T197043 WP_252025426.1 NZ_CP071849:c56632-56507 [Vibrio sp. SCSIO 43136]
MFCYLEGKNIKVLHAFVKKSQKAPKKDIKLARDRMREVKNE

Download         Length: 126 bp

>T197043 NZ_CP095533:c3101642-3101539 [Escherichia coli]
GGCAAGGCATCTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10024.50 Da        Isoelectric Point: 6.9490

>AT197043 WP_252025423.1 NZ_CP071849:c56514-56236 [Vibrio sp. SCSIO 43136]
MSSLQSLKDKALVNPDVKAEYDALEPEFELISMLLSMRESAGLTQAQVAERMGTKESNISRLEKGTGNPTIKTLAKYAKA
CGCQLNFGFTHA

Download         Length: 279 bp

>AT197043 NZ_CP095533:3101501-3101772 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGATGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References