Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1230204..1230907 Replicon chromosome
Accession NZ_CP071848
Organism Vibrio sp. SCSIO 43136

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag J4N39_RS05795 Protein ID WP_252023001.1
Coordinates 1230204..1230617 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag J4N39_RS05800 Protein ID WP_252023003.1
Coordinates 1230614..1230907 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N39_RS05780 (J4N39_05780) 1225724..1226647 + 924 WP_252022995.1 23S rRNA pseudouridine(2605) synthase RluB -
J4N39_RS05785 (J4N39_05785) 1226887..1228026 + 1140 WP_252022996.1 SIR2 family protein -
J4N39_RS05790 (J4N39_05790) 1228023..1229831 + 1809 WP_252022999.1 ATP-binding protein -
J4N39_RS05795 (J4N39_05795) 1230204..1230617 - 414 WP_252023001.1 type II toxin-antitoxin system YafO family toxin Toxin
J4N39_RS05800 (J4N39_05800) 1230614..1230907 - 294 WP_252023003.1 hypothetical protein Antitoxin
J4N39_RS05805 (J4N39_05805) 1231205..1231630 - 426 WP_252023005.1 hypothetical protein -
J4N39_RS05810 (J4N39_05810) 1231698..1232093 - 396 WP_252023008.1 hypothetical protein -
J4N39_RS05815 (J4N39_05815) 1232308..1232763 - 456 WP_252023010.1 hypothetical protein -
J4N39_RS05820 (J4N39_05820) 1232833..1233153 - 321 WP_252023012.1 HI1450 family dsDNA-mimic protein -
J4N39_RS05825 (J4N39_05825) 1233156..1233722 - 567 WP_252023014.1 elongation factor P-like protein YeiP -
J4N39_RS05830 (J4N39_05830) 1234237..1235034 + 798 WP_252023016.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(33-135)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15924.18 Da        Isoelectric Point: 6.9118

>T197039 WP_252023001.1 NZ_CP071848:c1230617-1230204 [Vibrio sp. SCSIO 43136]
VKDKPLKVRIFKHKILIEALSENELEALISDFKTYKETGQKPDTFGRDEAYDHPNTLPILKSEEVRHIHLAAHDAPFLSA
VQFYQTSDKHLVYCQGWEDPKCYLLIAILAPDAHEQARNRNIMHNLGVIAERFRQQF

Download         Length: 414 bp

>T197039 NZ_CP095533:c2412237-2412130 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10603.94 Da        Isoelectric Point: 4.4678

>AT197039 WP_252023003.1 NZ_CP071848:c1230907-1230614 [Vibrio sp. SCSIO 43136]
MKTSTIYAEKAVSSSEARKHFKDCLSGEPVVVLSNNEPAGYMMSADFFEGLMKALEDKNPNSVASFRPMTARLDAIAQLN
AKALADLDENDIGNFQE

Download         Length: 294 bp

>AT197039 NZ_CP095533:2412290-2412351 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References