Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 373574..374225 Replicon chromosome
Accession NZ_CP071848
Organism Vibrio sp. SCSIO 43136

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4N39_RS01915 Protein ID WP_252021425.1
Coordinates 373878..374225 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4N39_RS01910 Protein ID WP_252021423.1
Coordinates 373574..373885 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N39_RS01890 (J4N39_01890) 370493..371113 + 621 WP_252021415.1 DNA-3-methyladenine glycosylase 2 family protein -
J4N39_RS01895 (J4N39_01895) 371229..372416 - 1188 WP_252021417.1 radical SAM family heme chaperone HemW -
J4N39_RS01900 (J4N39_01900) 372413..373015 - 603 WP_252021419.1 XTP/dITP diphosphatase -
J4N39_RS01905 (J4N39_01905) 373096..373539 - 444 WP_252021421.1 DUF4426 domain-containing protein -
J4N39_RS01910 (J4N39_01910) 373574..373885 - 312 WP_252021423.1 XRE family transcriptional regulator Antitoxin
J4N39_RS01915 (J4N39_01915) 373878..374225 - 348 WP_252021425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N39_RS01920 (J4N39_01920) 374332..374622 - 291 WP_252021427.1 DUF167 family protein YggU -
J4N39_RS01925 (J4N39_01925) 374622..375179 - 558 WP_252021429.1 YggT family protein -
J4N39_RS01930 (J4N39_01930) 375214..376032 - 819 WP_252021431.1 pyrroline-5-carboxylate reductase -
J4N39_RS01935 (J4N39_01935) 376057..376761 - 705 WP_252021433.1 YggS family pyridoxal phosphate-dependent enzyme -
J4N39_RS01940 (J4N39_01940) 376786..377832 + 1047 WP_252021435.1 type IV pilus twitching motility protein PilT -
J4N39_RS01945 (J4N39_01945) 377843..378952 + 1110 WP_252021437.1 PilT/PilU family type 4a pilus ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13218.96 Da        Isoelectric Point: 7.3582

>T197036 WP_252021425.1 NZ_CP071848:c374225-373878 [Vibrio sp. SCSIO 43136]
MWNIETRARFDDWYWSLTDPDRISIQASLLVLAEKGAQLGRPHADSLHGSKHSNMKELRVQSQGRPIRIFFAFDPERTGI
VLCGGDKSGDKRFYRTMIPIADAEYDKHLEELKNG

Download         Length: 348 bp

>T197036 NZ_CP095533:c1540456-1540238 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11484.47 Da        Isoelectric Point: 8.0087

>AT197036 WP_252021423.1 NZ_CP071848:c373885-373574 [Vibrio sp. SCSIO 43136]
MAKQSKPLSELLAKEKPEVLEQARLKADEMLLDLRLAEIRTLTNQSQVQIAQAMGVTQPTIASLEKKGKDVRLMSLKRYV
EAAGCKLRIDIEMPDGSSHELPI

Download         Length: 312 bp

>AT197036 NZ_CP095533:c1540856-1540482 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References