Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 72912..73645 | Replicon | plasmid unnamed |
| Accession | NZ_CP071844 | ||
| Organism | Vibrio sp. SCSIO 43009 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | J4N43_RS24180 | Protein ID | WP_252094209.1 |
| Coordinates | 72912..73229 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0P7ER46 |
| Locus tag | J4N43_RS24185 | Protein ID | WP_025998577.1 |
| Coordinates | 73232..73645 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4N43_RS24150 (J4N43_24020) | 68778..69680 | + | 903 | WP_252094207.1 | homocysteine S-methyltransferase family protein | - |
| J4N43_RS24155 (J4N43_24025) | 69667..71202 | + | 1536 | WP_252094208.1 | BCCT family transporter | - |
| J4N43_RS24160 (J4N43_24030) | 71477..71758 | + | 282 | WP_000086647.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J4N43_RS24165 (J4N43_24035) | 71755..72041 | + | 287 | Protein_68 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J4N43_RS24170 (J4N43_24040) | 72169..72486 | - | 318 | WP_017634137.1 | CcdB family protein | - |
| J4N43_RS24175 (J4N43_24045) | 72486..72731 | - | 246 | WP_054579197.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| J4N43_RS24180 (J4N43_24050) | 72912..73229 | + | 318 | WP_252094209.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| J4N43_RS24185 (J4N43_24055) | 73232..73645 | + | 414 | WP_025998577.1 | hypothetical protein | Antitoxin |
| J4N43_RS24190 (J4N43_24060) | 73672..74088 | + | 417 | WP_252094210.1 | hypothetical protein | - |
| J4N43_RS24195 (J4N43_24065) | 74820..75479 | + | 660 | WP_252094211.1 | hypothetical protein | - |
| J4N43_RS24200 (J4N43_24070) | 75494..75586 | + | 93 | WP_113795351.1 | DUF3265 domain-containing protein | - |
| J4N43_RS24205 (J4N43_24075) | 75623..76288 | + | 666 | WP_252094212.1 | DUF6338 family protein | - |
| J4N43_RS24210 (J4N43_24080) | 76438..76530 | + | 93 | WP_197072411.1 | DUF3265 domain-containing protein | - |
| J4N43_RS24215 (J4N43_24085) | 76562..77341 | + | 780 | WP_252094213.1 | hypothetical protein | - |
| J4N43_RS24220 (J4N43_24090) | 77370..78324 | - | 955 | Protein_79 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..135905 | 135905 | |
| - | inside | Integron | - | - | 71755..80936 | 9181 | |
| - | flank | IS/Tn | - | - | 77444..78133 | 689 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12141.14 Da Isoelectric Point: 10.1262
>T197027 WP_252094209.1 NZ_CP071844:72912-73229 [Vibrio sp. SCSIO 43009]
MHVIKREPFETAKRLYPQCAEALDSTFKTLKATKAKRPEQLKQLFPSLDNFKYVDKWYVIDIGGGSLRLIAFIEFTGGKC
FVKYIVTHAEYDKIADQHRTKGKRG
MHVIKREPFETAKRLYPQCAEALDSTFKTLKATKAKRPEQLKQLFPSLDNFKYVDKWYVIDIGGGSLRLIAFIEFTGGKC
FVKYIVTHAEYDKIADQHRTKGKRG
Download Length: 318 bp
>T197027 NZ_CP095529:c4136950-4136636 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15845.18 Da Isoelectric Point: 4.5932
>AT197027 WP_025998577.1 NZ_CP071844:73232-73645 [Vibrio sp. SCSIO 43009]
MNIQALKTLSNEIHTAMPWLQGIRDHEQYLELMELMDTLVEDYEENHVLIDLLFPVLERYEEESEHFQEFNAHIDSLDTG
IATLRVLIDQYRLTLSDLPEIGGKSLVSLILSGKRQLTVGHIKALSERFGVPKHMFI
MNIQALKTLSNEIHTAMPWLQGIRDHEQYLELMELMDTLVEDYEENHVLIDLLFPVLERYEEESEHFQEFNAHIDSLDTG
IATLRVLIDQYRLTLSDLPEIGGKSLVSLILSGKRQLTVGHIKALSERFGVPKHMFI
Download Length: 414 bp
>AT197027 NZ_CP095529:c4136639-4136223 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACGCCCAGGCGCTGGAACTGGTCGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACGCCCAGGCGCTGGAACTGGTCGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|