Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 24415..25130 Replicon plasmid unnamed
Accession NZ_CP071844
Organism Vibrio sp. SCSIO 43009

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4N43_RS23930 Protein ID WP_252094225.1
Coordinates 24415..24702 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4N43_RS23935 Protein ID WP_252094226.1
Coordinates 24801..25130 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N43_RS23910 (J4N43_23785) 19505..22162 - 2658 WP_252094222.1 hypothetical protein -
J4N43_RS23915 (J4N43_23790) 22291..23103 - 813 WP_074190819.1 hypothetical protein -
J4N43_RS23920 (J4N43_23795) 23103..23618 - 516 WP_252094223.1 hypothetical protein -
J4N43_RS23925 23630..24190 - 561 WP_252094224.1 hypothetical protein -
J4N43_RS23930 (J4N43_23805) 24415..24702 + 288 WP_252094225.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N43_RS23935 (J4N43_23810) 24801..25130 + 330 WP_252094226.1 HigA family addiction module antitoxin Antitoxin
J4N43_RS23940 (J4N43_23815) 25284..26621 + 1338 WP_252094227.1 Fic family protein -
J4N43_RS23945 (J4N43_23820) 26687..27184 - 498 WP_042522736.1 hypothetical protein -
J4N43_RS23950 (J4N43_23825) 27198..27806 - 609 WP_252094228.1 hypothetical protein -
J4N43_RS23955 (J4N43_23830) 27816..28484 - 669 WP_171343314.1 hypothetical protein -
J4N43_RS23960 (J4N43_23835) 28507..30081 - 1575 WP_252094229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..135905 135905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11290.75 Da        Isoelectric Point: 5.7154

>T197026 WP_252094225.1 NZ_CP071844:24415-24702 [Vibrio sp. SCSIO 43009]
MEFKTQYLEDFYVDDISHKKIPSNLEDVLYRKLEMLDAATDFRDLLAPPNNRFERLSGKLSGYCSIRVNKQYRLVFKFDN
GEVTDTYLDPHTYRA

Download         Length: 288 bp

>T197026 NZ_CP095529:c3893837-3893430 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12111.94 Da        Isoelectric Point: 7.2045

>AT197026 WP_252094226.1 NZ_CP071844:24801-25130 [Vibrio sp. SCSIO 43009]
MRRTKRKPVTVGEMLKVEFLEPLSITNSTLAEAMGVHRNTISNIINGKTTLTSELATKLAVALGNTPEFWLNIQHAVDVW
ESNNSFEDTKLSVKPLVKFDSSMSDFAMA

Download         Length: 330 bp

>AT197026 NZ_CP095529:c3894084-3893818 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References