Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 242002..242617 Replicon chromosome
Accession NZ_CP071826
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4G50_RS20160 Protein ID WP_208000484.1
Coordinates 242276..242617 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4G50_RS20155 Protein ID WP_096500685.1
Coordinates 242002..242289 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS20125 237483..238304 + 822 WP_207999763.1 SDR family oxidoreductase -
J4G50_RS20130 238409..239188 - 780 WP_096500691.1 5'/3'-nucleotidase SurE -
J4G50_RS20135 239386..239685 - 300 WP_096501034.1 AzlD family protein -
J4G50_RS20140 239678..240415 - 738 WP_098554568.1 AzlC family ABC transporter permease -
J4G50_RS20145 240541..240999 + 459 WP_096500687.1 Lrp/AsnC family transcriptional regulator -
J4G50_RS20150 241225..241794 + 570 WP_174925115.1 hypothetical protein -
J4G50_RS20155 242002..242289 - 288 WP_096500685.1 helix-turn-helix transcriptional regulator Antitoxin
J4G50_RS20160 242276..242617 - 342 WP_208000484.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G50_RS20165 242850..243482 - 633 WP_207999764.1 LysE family transporter -
J4G50_RS20170 243659..244519 - 861 WP_207999765.1 hypothetical protein -
J4G50_RS20175 244570..244902 - 333 WP_207999766.1 DUF2322 family protein -
J4G50_RS20180 245023..245727 - 705 WP_207999767.1 flavin reductase -
J4G50_RS20185 245958..246284 + 327 WP_098554576.1 thioredoxin family protein -
J4G50_RS20190 246295..246714 + 420 WP_096501030.1 secondary thiamine-phosphate synthase enzyme YjbQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13014.20 Da        Isoelectric Point: 9.8290

>T197009 WP_208000484.1 NZ_CP071826:c242617-242276 [Burkholderia anthina]
MMATAYEIQFFDTRVETGVITLPKTLLARFFALADRMEQYGPNLGEPHTQSMGNGLYEMRLKGAEGIARVFYCAIVDRRI
VMLHCFVKKTQKTPRKELETARRRLKEVQDGNV

Download         Length: 342 bp

>T197009 NZ_CP095528:c3516-3367 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10389.97 Da        Isoelectric Point: 9.9960

>AT197009 WP_096500685.1 NZ_CP071826:c242289-242002 [Burkholderia anthina]
MATYKALRERALSDPEVRAEYERLNREDLALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYATACGKKLVISFA

Download         Length: 288 bp

>AT197009 NZ_CP095528:3564-3620 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References