Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2210777..2211296 Replicon chromosome
Accession NZ_CP071806
Organism Streptococcus suis strain GX69

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag JZ789_RS10985 Protein ID WP_013730620.1
Coordinates 2210777..2211034 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag JZ789_RS10990 Protein ID WP_002939010.1
Coordinates 2211036..2211296 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ789_RS10970 (JZ789_10885) 2207248..2208978 - 1731 WP_009910905.1 membrane protein -
JZ789_RS10975 (JZ789_10890) 2209341..2210213 - 873 WP_009910907.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
JZ789_RS10980 (JZ789_10895) 2210233..2210763 - 531 WP_009910909.1 DUF1697 domain-containing protein -
JZ789_RS10985 (JZ789_10900) 2210777..2211034 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
JZ789_RS10990 (JZ789_10905) 2211036..2211296 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JZ789_RS10995 (JZ789_10910) 2211372..2211827 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
JZ789_RS11000 (JZ789_10915) 2211831..2212199 - 369 WP_013730622.1 hypothetical protein -
JZ789_RS11005 (JZ789_10920) 2212192..2212761 - 570 WP_022540720.1 ribonuclease M5 -
JZ789_RS11010 (JZ789_10925) 2212745..2213527 - 783 WP_002939015.1 TatD family hydrolase -
JZ789_RS11015 (JZ789_10930) 2213635..2213772 - 138 WP_002939016.1 50S ribosomal protein L34 -
JZ789_RS11020 (JZ789_10935) 2213940..2214935 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
JZ789_RS11025 (JZ789_10940) 2214955..2215767 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
JZ789_RS11030 (JZ789_10945) 2215751..2216110 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T196971 WP_013730620.1 NZ_CP071806:c2211034-2210777 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T196971 NZ_CP095520:925684-925986 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT196971 WP_002939010.1 NZ_CP071806:c2211296-2211036 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT196971 NZ_CP095520:926022-926363 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References