Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2215106..2215692 Replicon chromosome
Accession NZ_CP071771
Organism Acinetobacter towneri strain GX7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4G46_RS10610 Protein ID WP_096900967.1
Coordinates 2215106..2215414 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag J4G46_RS10615 Protein ID WP_004971994.1
Coordinates 2215411..2215692 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G46_RS10590 (J4G46_10590) 2210856..2211323 + 468 WP_179996144.1 GNAT family N-acetyltransferase -
J4G46_RS10595 (J4G46_10595) 2211425..2213041 - 1617 WP_208011884.1 sulfate adenylyltransferase subunit CysN -
J4G46_RS10600 (J4G46_10600) 2213186..2214094 - 909 WP_026438300.1 sulfate adenylyltransferase subunit CysD -
J4G46_RS10605 (J4G46_10605) 2214449..2214979 + 531 WP_096900966.1 hypothetical protein -
J4G46_RS10610 (J4G46_10610) 2215106..2215414 + 309 WP_096900967.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G46_RS10615 (J4G46_10615) 2215411..2215692 + 282 WP_004971994.1 HigA family addiction module antitoxin Antitoxin
J4G46_RS10620 (J4G46_10620) 2215766..2217292 - 1527 WP_096900968.1 lysine--tRNA ligase -
J4G46_RS10625 (J4G46_10625) 2217609..2218115 + 507 WP_026438299.1 YqiA/YcfP family alpha/beta fold hydrolase -
J4G46_RS10630 (J4G46_10630) 2218226..2218768 - 543 WP_004972003.1 adenine phosphoribosyltransferase -
J4G46_RS10635 (J4G46_10635) 2219253..2219417 + 165 WP_004972007.1 rubredoxin RubA -
J4G46_RS10640 (J4G46_10640) 2219490..2220668 + 1179 WP_208011885.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11454.04 Da        Isoelectric Point: 10.2252

>T196903 WP_096900967.1 NZ_CP071771:2215106-2215414 [Acinetobacter towneri]
MIKSFKHKGLQAFFQTGSTAGIQAAHSTKLRLILAALHAASTVNDLRTPPNWRLHKLSGNLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYHIASSAGVQR

Download         Length: 309 bp

>T196903 NZ_CP095510:c2255921-2255547 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10451.10 Da        Isoelectric Point: 6.7228

>AT196903 WP_004971994.1 NZ_CP071771:2215411-2215692 [Acinetobacter towneri]
MNMMFNAPHPGEMLREYIGETSVTEVAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQHDLWLASQ
RQRPMIKKLVASV

Download         Length: 282 bp

>AT196903 NZ_CP095510:c2256378-2256010 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References