Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1950892..1951478 Replicon chromosome
Accession NZ_CP071770
Organism Acinetobacter towneri strain GX5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4G45_RS10405 Protein ID WP_207973524.1
Coordinates 1950892..1951200 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag J4G45_RS10410 Protein ID WP_004971994.1
Coordinates 1951197..1951478 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G45_RS10385 (J4G45_10390) 1946642..1947109 + 468 WP_131261606.1 GNAT family N-acetyltransferase -
J4G45_RS10390 (J4G45_10395) 1947211..1948827 - 1617 WP_096900965.1 sulfate adenylyltransferase subunit CysN -
J4G45_RS10395 (J4G45_10400) 1948972..1949880 - 909 WP_026438300.1 sulfate adenylyltransferase subunit CysD -
J4G45_RS10400 (J4G45_10405) 1950235..1950765 + 531 WP_096900966.1 hypothetical protein -
J4G45_RS10405 (J4G45_10410) 1950892..1951200 + 309 WP_207973524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G45_RS10410 (J4G45_10415) 1951197..1951478 + 282 WP_004971994.1 HigA family addiction module antitoxin Antitoxin
J4G45_RS10415 (J4G45_10420) 1951552..1953078 - 1527 WP_096900968.1 lysine--tRNA ligase -
J4G45_RS10420 (J4G45_10425) 1953395..1953901 + 507 WP_026438299.1 YqiA/YcfP family alpha/beta fold hydrolase -
J4G45_RS10425 (J4G45_10430) 1954012..1954554 - 543 WP_004972003.1 adenine phosphoribosyltransferase -
J4G45_RS10430 (J4G45_10435) 1955039..1955203 + 165 WP_004972007.1 rubredoxin RubA -
J4G45_RS10435 (J4G45_10440) 1955276..1956454 + 1179 WP_096900969.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11481.07 Da        Isoelectric Point: 10.2252

>T196897 WP_207973524.1 NZ_CP071770:1950892-1951200 [Acinetobacter towneri]
MIKSFKHKGLQAFFQTGSTAGIQAAHSTKLRLILAALHAASTVNDLRTPPNWRLHKLNGNLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYHIASSAGVQR

Download         Length: 309 bp

>T196897 NZ_CP095510:923856-924170 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10451.10 Da        Isoelectric Point: 6.7228

>AT196897 WP_004971994.1 NZ_CP071770:1951197-1951478 [Acinetobacter towneri]
MNMMFNAPHPGEMLREYIGETSVTEVAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQHDLWLASQ
RQRPMIKKLVASV

Download         Length: 282 bp

>AT196897 NZ_CP095510:924167-924583 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACGCCCAGGCGCTGGAACTGGTCGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References