Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 115279..115864 Replicon plasmid pGX3-1
Accession NZ_CP071767
Organism Acinetobacter towneri strain GX3

Toxin (Protein)


Gene name higB Uniprot ID N9CJF7
Locus tag J4G44_RS13075 Protein ID WP_000897307.1
Coordinates 115279..115599 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4G44_RS13080 Protein ID WP_000369781.1
Coordinates 115592..115864 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G44_RS13040 (J4G44_13040) 110951..111328 + 378 Protein_105 AraC family ligand binding domain-containing protein -
J4G44_RS13595 111307..111500 + 194 Protein_106 BrnT family toxin -
J4G44_RS13045 (J4G44_13045) 111487..111801 + 315 WP_004728120.1 BrnA antitoxin family protein -
J4G44_RS13050 (J4G44_13050) 111890..112420 - 531 WP_000172759.1 hypothetical protein -
J4G44_RS13055 (J4G44_13055) 112569..112871 + 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4G44_RS13060 (J4G44_13060) 112872..113153 + 282 WP_000985609.1 putative addiction module antidote protein -
J4G44_RS13065 (J4G44_13065) 113244..114569 - 1326 WP_096902756.1 ISNCY family transposase -
J4G44_RS13070 (J4G44_13070) 114720..115139 - 420 WP_001180106.1 SMI1/KNR4 family protein -
J4G44_RS13075 (J4G44_13075) 115279..115599 + 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G44_RS13080 (J4G44_13080) 115592..115864 + 273 WP_000369781.1 NadS family protein Antitoxin
J4G44_RS13085 (J4G44_13085) 115975..116934 - 960 WP_180006246.1 IS30 family transposase -
J4G44_RS13090 (J4G44_13090) 117432..118904 + 1473 Protein_116 ABC-F type ribosomal protection protein Msr(E) -
J4G44_RS13095 (J4G44_13095) 118960..119841 + 882 Protein_117 Mph(E) family macrolide 2'-phosphotransferase -
J4G44_RS13100 (J4G44_13100) 120030..120641 - 612 WP_015060246.1 recombinase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / tet(X3) / sul2 / dfrA20 / floR / blaOXA-58 / msr(E) / mph(E) - 1..148166 148166
- inside IScluster/Tn blaOXA-58 / msr(E) / mph(E) - 107217..119740 12523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(41-102)

Antitoxin

(37-85)


Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.95 Da        Isoelectric Point: 7.1639

>T196886 WP_000897307.1 NZ_CP071767:115279-115599 [Acinetobacter towneri]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Download         Length: 321 bp

>T196886 NZ_CP095505:c3277694-3277317 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT196886 WP_000369781.1 NZ_CP071767:115592-115864 [Acinetobacter towneri]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT196886 NZ_CP095505:c3278151-3277771 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A8TMZ3


Antitoxin

Source ID Structure

References