Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1323206..1323792 Replicon chromosome
Accession NZ_CP071766
Organism Acinetobacter towneri strain GX3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4G44_RS06305 Protein ID WP_207973524.1
Coordinates 1323484..1323792 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag J4G44_RS06300 Protein ID WP_004971994.1
Coordinates 1323206..1323487 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G44_RS06275 (J4G44_06275) 1318230..1319408 - 1179 WP_096900969.1 FAD-dependent oxidoreductase -
J4G44_RS06280 (J4G44_06280) 1319481..1319645 - 165 WP_004972007.1 rubredoxin RubA -
J4G44_RS06285 (J4G44_06285) 1320130..1320672 + 543 WP_004972003.1 adenine phosphoribosyltransferase -
J4G44_RS06290 (J4G44_06290) 1320783..1321289 - 507 WP_026438299.1 YqiA/YcfP family alpha/beta fold hydrolase -
J4G44_RS06295 (J4G44_06295) 1321606..1323132 + 1527 WP_096900968.1 lysine--tRNA ligase -
J4G44_RS06300 (J4G44_06300) 1323206..1323487 - 282 WP_004971994.1 HigA family addiction module antitoxin Antitoxin
J4G44_RS06305 (J4G44_06305) 1323484..1323792 - 309 WP_207973524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G44_RS06310 (J4G44_06310) 1323919..1324449 - 531 WP_096900966.1 hypothetical protein -
J4G44_RS06315 (J4G44_06315) 1324804..1325712 + 909 WP_026438300.1 sulfate adenylyltransferase subunit CysD -
J4G44_RS06320 (J4G44_06320) 1325857..1327473 + 1617 WP_096900965.1 sulfate adenylyltransferase subunit CysN -
J4G44_RS06325 (J4G44_06325) 1327575..1328042 - 468 WP_131261606.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11481.07 Da        Isoelectric Point: 10.2252

>T196879 WP_207973524.1 NZ_CP071766:c1323792-1323484 [Acinetobacter towneri]
MIKSFKHKGLQAFFQTGSTAGIQAAHSTKLRLILAALHAASTVNDLRTPPNWRLHKLNGNLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYHIASSAGVQR

Download         Length: 309 bp

>T196879 NZ_CP095505:c1473256-1472945 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGCGCGCGCAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAAGCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10451.10 Da        Isoelectric Point: 6.7228

>AT196879 WP_004971994.1 NZ_CP071766:c1323487-1323206 [Acinetobacter towneri]
MNMMFNAPHPGEMLREYIGETSVTEVAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQHDLWLASQ
RQRPMIKKLVASV

Download         Length: 282 bp

>AT196879 NZ_CP095505:c1472948-1472529 [Escherichia coli]
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References