Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1300459..1301116 Replicon chromosome
Accession NZ_CP071751
Organism Burkholderia pseudomallei strain VBM23831

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J3C54_RS05660 Protein ID WP_009972517.1
Coordinates 1300784..1301116 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J3C54_RS05655 Protein ID WP_009972518.1
Coordinates 1300459..1300776 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3C54_RS05630 (J3C54_05630) 1296443..1297312 - 870 WP_004189208.1 patatin-like phospholipase family protein -
J3C54_RS05635 (J3C54_05635) 1297350..1297754 - 405 WP_004200732.1 PaaI family thioesterase -
J3C54_RS05645 (J3C54_05645) 1298369..1299031 - 663 WP_133670743.1 MAE_28990/MAE_18760 family HEPN-like nuclease -
J3C54_RS05650 (J3C54_05650) 1299052..1300296 - 1245 WP_223873300.1 DUF262 domain-containing protein -
J3C54_RS05655 (J3C54_05655) 1300459..1300776 - 318 WP_009972518.1 helix-turn-helix domain-containing protein Antitoxin
J3C54_RS05660 (J3C54_05660) 1300784..1301116 - 333 WP_009972517.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3C54_RS05670 (J3C54_05670) 1302703..1303185 + 483 WP_004200731.1 DUF2778 domain-containing protein -
J3C54_RS05675 (J3C54_05675) 1303182..1303466 + 285 WP_004188977.1 hypothetical protein -
J3C54_RS05680 (J3C54_05680) 1303539..1304594 - 1056 WP_038785926.1 phage portal protein -
J3C54_RS05685 (J3C54_05685) 1304591..1305085 - 495 Protein_1131 terminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1296443..1305076 8633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-100)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12820.92 Da        Isoelectric Point: 10.3618

>T196847 WP_009972517.1 NZ_CP071751:c1301116-1300784 [Burkholderia pseudomallei]
MKLDWTVIYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGQQVV
VLHSFVKKTQETPQRELRIAQARLREVRNG

Download         Length: 333 bp

>T196847 NZ_CP095448:c4617113-4616940 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11321.89 Da        Isoelectric Point: 10.2231

>AT196847 WP_009972518.1 NZ_CP071751:c1300776-1300459 [Burkholderia pseudomallei]
VKRVRAEGFNPVPHTADDTVRLLAGRNVKTAYDALEDEYTALRAILSARREAGLTQAQIAERMGTTASAVSRLEASLSSE
KHSPSFATLRKYAAACGKKLVISFA

Download         Length: 318 bp

>AT196847 NZ_CP095448:c4617437-4617141 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References