Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 193830..194487 Replicon chromosome
Accession NZ_CP071749
Organism Burkholderia pseudomallei strain VBM21885

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J3B47_RS00890 Protein ID WP_187328920.1
Coordinates 193830..194174 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J3B47_RS00895 Protein ID WP_243435429.1
Coordinates 194212..194487 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3B47_RS00865 (J3B47_00865) 189025..189951 + 927 WP_011852346.1 zonular occludens toxin domain-containing protein -
J3B47_RS00870 (J3B47_00870) 189948..191294 + 1347 WP_038726519.1 type II secretory pathway protein -
J3B47_RS00875 (J3B47_00875) 191308..191541 - 234 WP_038726517.1 hypothetical protein -
J3B47_RS00880 (J3B47_00880) 192056..192835 + 780 WP_038799540.1 hypothetical protein -
J3B47_RS00885 (J3B47_00885) 193121..193789 + 669 WP_243435409.1 site-specific integrase -
J3B47_RS00890 (J3B47_00890) 193830..194174 + 345 WP_187328920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3B47_RS00895 (J3B47_00895) 194212..194487 + 276 WP_243435429.1 helix-turn-helix transcriptional regulator Antitoxin
J3B47_RS31430 194667..194900 + 234 WP_131201521.1 hypothetical protein -
J3B47_RS00900 (J3B47_00900) 195390..195932 + 543 WP_131201532.1 PAAR domain-containing protein -
J3B47_RS00905 (J3B47_00905) 195929..196642 + 714 WP_207865924.1 VRR-NUC domain-containing protein -
J3B47_RS00910 (J3B47_00910) 196642..197721 + 1080 WP_151271492.1 DUF3396 domain-containing protein -
J3B47_RS00915 (J3B47_00915) 198189..198422 + 234 WP_131201523.1 hypothetical protein -
J3B47_RS00920 (J3B47_00920) 198597..199010 + 414 WP_131201524.1 very short patch repair endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 180960..202889 21929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13104.18 Da        Isoelectric Point: 10.1007

>T196841 WP_187328920.1 NZ_CP071749:193830-194174 [Burkholderia pseudomallei]
MKQNWTVVYYNERVKRDVFALPAGILADYLRLLDLMQEFGADLRMPHSRAMGDGLFELRPKGREGIGRVLYCTHFGRHVV
VLHSFVKKTQEAPQKELRTARARLSEVRNGESGC

Download         Length: 345 bp

>T196841 NZ_CP095448:3686597-3687139 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9806.08 Da        Isoelectric Point: 8.0016

>AT196841 WP_243435429.1 NZ_CP071749:194212-194487 [Burkholderia pseudomallei]
MTDDTERLLAKPGVKAQYDALEDEYSALRAILTARQDAGLTQAQVAERMGTTASAVSRLEASLSSERHSPSFATLRKYAA
ACGKRLVISFA

Download         Length: 276 bp

>AT196841 NZ_CP095448:3686302-3686613 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGCCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References