Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 96900..97624 | Replicon | plasmid pKGB1a |
| Accession | NZ_CP071736 | ||
| Organism | Klebsiella variicola strain KGB_1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A2J4YLV3 |
| Locus tag | KGB1_RS27950 | Protein ID | WP_023292165.1 |
| Coordinates | 97313..97624 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KGB1_RS27945 | Protein ID | WP_049010942.1 |
| Coordinates | 96900..97316 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KGB1_RS27915 (KGB1_27895) | 92484..92891 | + | 408 | WP_253616198.1 | transglycosylase SLT domain-containing protein | - |
| KGB1_RS27920 (KGB1_27900) | 92928..93458 | - | 531 | WP_087846439.1 | antirestriction protein | - |
| KGB1_RS27925 (KGB1_27905) | 94083..94916 | - | 834 | WP_253616138.1 | N-6 DNA methylase | - |
| KGB1_RS27930 (KGB1_27910) | 94962..95192 | - | 231 | WP_047722596.1 | hypothetical protein | - |
| KGB1_RS27935 (KGB1_27915) | 95279..95626 | - | 348 | WP_114501446.1 | hypothetical protein | - |
| KGB1_RS27940 (KGB1_27920) | 95692..96072 | - | 381 | WP_240289755.1 | hypothetical protein | - |
| KGB1_RS27945 (KGB1_27925) | 96900..97316 | - | 417 | WP_049010942.1 | helix-turn-helix domain-containing protein | Antitoxin |
| KGB1_RS27950 (KGB1_27930) | 97313..97624 | - | 312 | WP_023292165.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| KGB1_RS27955 (KGB1_27935) | 97731..97955 | - | 225 | WP_240289756.1 | hypothetical protein | - |
| KGB1_RS27960 (KGB1_27940) | 97966..98178 | - | 213 | WP_049157092.1 | hypothetical protein | - |
| KGB1_RS27965 (KGB1_27945) | 98239..98595 | - | 357 | WP_211754325.1 | hypothetical protein | - |
| KGB1_RS27970 (KGB1_27950) | 99425..99958 | - | 534 | Protein_112 | IS110 family transposase | - |
| KGB1_RS27975 (KGB1_27955) | 100169..100684 | + | 516 | WP_049156577.1 | RNA polymerase sigma factor | - |
| KGB1_RS27980 (KGB1_27960) | 100674..101654 | + | 981 | WP_117110158.1 | FecR family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..160574 | 160574 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12497.32 Da Isoelectric Point: 9.9242
>T196834 WP_023292165.1 NZ_CP071736:c97624-97313 [Klebsiella variicola]
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
Download Length: 312 bp
>T196834 NZ_CP095448:c2103268-2102774 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG
Antitoxin
Download Length: 139 a.a. Molecular weight: 15438.52 Da Isoelectric Point: 4.4711
>AT196834 WP_049010942.1 NZ_CP071736:c97316-96900 [Klebsiella variicola]
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
Download Length: 417 bp
>AT196834 NZ_CP095448:c2103558-2103265 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|