Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 812838..813519 Replicon chromosome
Accession NZ_CP071730
Organism Pseudomonas aeruginosa strain LYSZa5

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag LYSZa5_RS03895 Protein ID WP_003111825.1
Coordinates 813154..813519 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag LYSZa5_RS03890 Protein ID WP_003159602.1
Coordinates 812838..813161 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSZa5_RS03855 (LYSZa5_03855) 808094..808972 + 879 WP_003163191.1 hypothetical protein -
LYSZa5_RS03865 (LYSZa5_03865) 809602..811311 + 1710 WP_003085674.1 TIGR04141 family sporadically distributed protein -
LYSZa5_RS30940 811297..812216 - 920 Protein_768 tyrosine-type recombinase/integrase -
LYSZa5_RS03880 (LYSZa5_03880) 812216..812608 - 393 Protein_769 hypothetical protein -
LYSZa5_RS03885 (LYSZa5_03885) 812603..812722 + 120 Protein_770 IS5/IS1182 family transposase -
LYSZa5_RS03890 (LYSZa5_03890) 812838..813161 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
LYSZa5_RS03895 (LYSZa5_03895) 813154..813519 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LYSZa5_RS30945 813810..813984 - 175 Protein_773 hypothetical protein -
LYSZa5_RS03900 (LYSZa5_03900) 814191..814463 + 273 WP_014603216.1 hypothetical protein -
LYSZa5_RS03905 (LYSZa5_03905) 814493..814918 - 426 WP_003116492.1 VOC family protein -
LYSZa5_RS03910 (LYSZa5_03910) 815019..815903 + 885 WP_023132251.1 LysR substrate-binding domain-containing protein -
LYSZa5_RS03915 (LYSZa5_03915) 815876..816829 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
LYSZa5_RS03920 (LYSZa5_03920) 817050..817484 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T196797 WP_003111825.1 NZ_CP071730:c813519-813154 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T196797 NZ_CP095426:c2801177-2799855 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT196797 WP_003159602.1 NZ_CP071730:c813161-812838 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT196797 NZ_CP095426:c2801443-2801177 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References