Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4869732..4870234 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag JQM62_RS23920 Protein ID WP_000767820.1
Coordinates 4869980..4870234 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JQM62_RS23915 Protein ID WP_001259255.1
Coordinates 4869732..4869983 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS23890 (4864909) 4864909..4865976 - 1068 WP_000080140.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JQM62_RS23895 (4865976) 4865976..4867046 - 1071 WP_000108928.1 histidinol-phosphate transaminase -
JQM62_RS23900 (4867043) 4867043..4868347 - 1305 WP_000009586.1 histidinol dehydrogenase -
JQM62_RS23905 (4868353) 4868353..4869252 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JQM62_RS23910 (4869398) 4869398..4869448 - 51 WP_001364200.1 his operon leader peptide -
JQM62_RS23915 (4869732) 4869732..4869983 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JQM62_RS23920 (4869980) 4869980..4870234 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JQM62_RS23925 (4870317) 4870317..4871141 + 825 WP_000754758.1 SDR family oxidoreductase -
JQM62_RS23930 (4871187) 4871187..4872116 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
JQM62_RS23935 (4872331) 4872331..4872393 + 63 WP_010723108.1 membrane protein YoeI -
JQM62_RS23940 (4872383) 4872383..4873741 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JQM62_RS23945 (4873920) 4873920..4874978 + 1059 WP_032276992.1 thiosulfate utilization transporter TsuA/YeeE -
JQM62_RS23950 (4874992) 4874992..4875219 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T196772 WP_000767820.1 NZ_CP071711:4869980-4870234 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T196772 NZ_CP095412:671517-671924 [Blastococcus sp. PRF04-17]
GTGATCCTTGCCGACACCTCTGCCTGGGTGGAGTTCGATCGGGCGACGGGCAGTGCCGTGGATCGGCGGATGACTGAATT
GATCGCCGTCGACGGCCCCCTCGCCGTCACGGAGCCCGTCCTCATGGAGGTACTCGCCGGCGCGCGCGATGACCAACGAG
CGGATGATCTCCGACGGTTGCTGCTGCGATGTCATCTGCTGGGGATTGATCCTGCCGCGGACTTCGATGCGGCTGCCCGC
GTCTACCGTCGCTGCCGGCGCGTCGGGGTGACCCCCCGCGGACTCCTGGACTGCCTGGTCGTCGCGGTGGCTTGGCGTAG
CGGAGCCAGCGTGCTCGCACAGGATGTCGACGTCGATCGCATCTGTGACGTCTTGGGTGTGCCTTCGGACCCGGGGGCGA
CGAACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT196772 WP_001259255.1 NZ_CP071711:4869732-4869983 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT196772 NZ_CP095412:671308-671520 [Blastococcus sp. PRF04-17]
ATGCCGCGGCTACGAACCAACATCGAGATCGAGGACGAACTCGTGCAGGTCGTGATGACCCGCTACGCAGTGAGGACCAA
GACGGAGGCGGTTGACCTCGCGCTGCGCCACTTGGCCGGCCAGCCGATGAGCCGCGATGAGGCGTTGTCCATGCGCGGTG
CCCGAGCGATGGAGGACGTCCCGGAGGATCACGCACCGCGTGGCGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References