Detailed information of TA system TA196754

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 426345..426565
• Replicon: chromosome
• Accession: NZ_CP071711
• Organism: Escherichia coli strain EC20017429

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: B7LGX8
• Locus tag: JQM62_RS02110
• Protein ID: WP_000170965.1
• Coordinates: 426458..426565 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	426345..426411 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQM62_RS02085	421624..423018	-	1395	WP_000086212.1	inverse autotransporter invasin YchO	-
JQM62_RS02090	423203..423556	+	354	WP_001169666.1	DsrE/F sulfur relay family protein YchN	-
JQM62_RS02095	423600..424295	-	696	WP_001297117.1	glutathione-specific gamma-glutamylcyclotransferase	-
JQM62_RS02100	424453..424683	-	231	WP_001146442.1	putative cation transport regulator ChaB	-
JQM62_RS02105	424953..426053	+	1101	WP_001295620.1	sodium-potassium/proton antiporter ChaA	-
-	426345..426411	-	67	-	-	Antitoxin
JQM62_RS02110	426458..426565	+	108	WP_000170965.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	426878..426941	-	64	NuclAT_33	-	-
-	426878..426941	-	64	NuclAT_33	-	-
-	426878..426941	-	64	NuclAT_33	-	-
-	426878..426941	-	64	NuclAT_33	-	-
-	426878..426941	-	64	NuclAT_35	-	-
-	426878..426941	-	64	NuclAT_35	-	-
-	426878..426941	-	64	NuclAT_35	-	-
-	426878..426941	-	64	NuclAT_35	-	-
-	426878..426941	-	64	NuclAT_37	-	-
-	426878..426941	-	64	NuclAT_37	-	-
-	426878..426941	-	64	NuclAT_37	-	-
-	426878..426941	-	64	NuclAT_37	-	-
-	426878..426941	-	64	NuclAT_39	-	-
-	426878..426941	-	64	NuclAT_39	-	-
-	426878..426941	-	64	NuclAT_39	-	-
-	426878..426941	-	64	NuclAT_39	-	-
-	426878..426941	-	64	NuclAT_41	-	-
-	426878..426941	-	64	NuclAT_41	-	-
-	426878..426941	-	64	NuclAT_41	-	-
-	426878..426941	-	64	NuclAT_41	-	-
-	426878..426941	-	64	NuclAT_43	-	-
-	426878..426941	-	64	NuclAT_43	-	-
-	426878..426941	-	64	NuclAT_43	-	-
-	426878..426941	-	64	NuclAT_43	-	-
-	426879..426941	-	63	NuclAT_45	-	-
-	426879..426941	-	63	NuclAT_45	-	-
-	426879..426941	-	63	NuclAT_45	-	-
-	426879..426941	-	63	NuclAT_45	-	-
-	426879..426941	-	63	NuclAT_48	-	-
-	426879..426941	-	63	NuclAT_48	-	-
-	426879..426941	-	63	NuclAT_48	-	-
-	426879..426941	-	63	NuclAT_48	-	-
-	426880..426941	-	62	NuclAT_15	-	-
-	426880..426941	-	62	NuclAT_15	-	-
-	426880..426941	-	62	NuclAT_15	-	-
-	426880..426941	-	62	NuclAT_15	-	-
-	426880..426941	-	62	NuclAT_18	-	-
-	426880..426941	-	62	NuclAT_18	-	-
-	426880..426941	-	62	NuclAT_18	-	-
-	426880..426941	-	62	NuclAT_18	-	-
-	426880..426941	-	62	NuclAT_21	-	-
-	426880..426941	-	62	NuclAT_21	-	-
-	426880..426941	-	62	NuclAT_21	-	-
-	426880..426941	-	62	NuclAT_21	-	-
-	426880..426941	-	62	NuclAT_24	-	-
-	426880..426941	-	62	NuclAT_24	-	-
-	426880..426941	-	62	NuclAT_24	-	-
-	426880..426941	-	62	NuclAT_24	-	-
-	426880..426941	-	62	NuclAT_27	-	-
-	426880..426941	-	62	NuclAT_27	-	-
-	426880..426941	-	62	NuclAT_27	-	-
-	426880..426941	-	62	NuclAT_27	-	-
-	426880..426941	-	62	NuclAT_30	-	-
-	426880..426941	-	62	NuclAT_30	-	-
-	426880..426941	-	62	NuclAT_30	-	-
-	426880..426941	-	62	NuclAT_30	-	-
JQM62_RS02115	426994..427101	+	108	WP_000170926.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	427415..427481	-	67	NuclAT_44	-	-
-	427415..427481	-	67	NuclAT_44	-	-
-	427415..427481	-	67	NuclAT_44	-	-
-	427415..427481	-	67	NuclAT_44	-	-
-	427415..427481	-	67	NuclAT_47	-	-
-	427415..427481	-	67	NuclAT_47	-	-
-	427415..427481	-	67	NuclAT_47	-	-
-	427415..427481	-	67	NuclAT_47	-	-
-	427416..427479	-	64	NuclAT_16	-	-
-	427416..427479	-	64	NuclAT_16	-	-
-	427416..427479	-	64	NuclAT_16	-	-
-	427416..427479	-	64	NuclAT_16	-	-
-	427416..427479	-	64	NuclAT_19	-	-
-	427416..427479	-	64	NuclAT_19	-	-
-	427416..427479	-	64	NuclAT_19	-	-
-	427416..427479	-	64	NuclAT_19	-	-
-	427416..427479	-	64	NuclAT_22	-	-
-	427416..427479	-	64	NuclAT_22	-	-
-	427416..427479	-	64	NuclAT_22	-	-
-	427416..427479	-	64	NuclAT_22	-	-
-	427416..427479	-	64	NuclAT_25	-	-
-	427416..427479	-	64	NuclAT_25	-	-
-	427416..427479	-	64	NuclAT_25	-	-
-	427416..427479	-	64	NuclAT_25	-	-
-	427416..427479	-	64	NuclAT_28	-	-
-	427416..427479	-	64	NuclAT_28	-	-
-	427416..427479	-	64	NuclAT_28	-	-
-	427416..427479	-	64	NuclAT_28	-	-
-	427416..427479	-	64	NuclAT_31	-	-
-	427416..427479	-	64	NuclAT_31	-	-
-	427416..427479	-	64	NuclAT_31	-	-
-	427416..427479	-	64	NuclAT_31	-	-
JQM62_RS02120	427529..427636	+	108	WP_000170954.1	type I toxin-antitoxin system toxin Ldr family protein	-
JQM62_RS02125	427785..428639	-	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
JQM62_RS02130	428675..429484	-	810	WP_001257037.1	invasion regulator SirB1	-
JQM62_RS02135	429488..429880	-	393	WP_000200392.1	invasion regulator SirB2	-
JQM62_RS02140	429877..430710	-	834	WP_000456459.1	peptide chain release factor N(5)-glutamine methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4001.77 Da
• Isoelectric Point: 11.4779

>T196754 WP_000170965.1 NZ_CP071711:426458-426565 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T196754 NZ_CP095377:2274049-2274786 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCAAAATTTAGCGATATTGGCAAGACAGTTCAATCCATAAAACGATC
ATTAATTGCATCTAAAGCAAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCTGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCACAATTTAGTATTATCGTCCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT196754 NZ_CP071711:c426411-426345 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y029

Antitoxin