Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1746266..1747622 Replicon chromosome
Accession NZ_CP071708
Organism Vibrio sp. ABG19

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag J0X00_RS14315 Protein ID WP_282477073.1
Coordinates 1746266..1747312 (-) Length 349 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag J0X00_RS14320 Protein ID WP_055467268.1
Coordinates 1747296..1747622 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0X00_RS14280 (J0X00_14275) 1741984..1742346 - 363 WP_282477068.1 conjugal transfer transcriptional regulator TraJ -
J0X00_RS14285 (J0X00_14280) 1742690..1743034 - 345 WP_282477069.1 TraK family protein -
J0X00_RS14290 (J0X00_14285) 1743036..1743275 - 240 WP_017048924.1 hypothetical protein -
J0X00_RS14295 (J0X00_14290) 1744243..1745043 + 801 WP_282477070.1 TIGR02391 family protein -
J0X00_RS14300 (J0X00_14295) 1745160..1745408 + 249 WP_188963142.1 hypothetical protein -
J0X00_RS14305 1745555..1745800 + 246 WP_282477071.1 hypothetical protein -
J0X00_RS14310 (J0X00_14300) 1746071..1746262 - 192 WP_282477072.1 hypothetical protein -
J0X00_RS14315 (J0X00_14305) 1746266..1747312 - 1047 WP_282477073.1 HipA domain-containing protein Toxin
J0X00_RS14320 (J0X00_14310) 1747296..1747622 - 327 WP_055467268.1 HipA N-terminal domain-containing protein Antitoxin
J0X00_RS14325 (J0X00_14315) 1747607..1747927 - 321 WP_282477074.1 helix-turn-helix transcriptional regulator -
J0X00_RS14330 (J0X00_14320) 1748211..1749302 - 1092 WP_282477075.1 site-specific integrase -
J0X00_RS14340 (J0X00_14330) 1749617..1751497 - 1881 WP_136483291.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1710668..1757580 46912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(60-309)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 349 a.a.        Molecular weight: 39598.97 Da        Isoelectric Point: 4.8085

>T196750 WP_282477073.1 NZ_CP071708:c1747312-1746266 [Vibrio sp. ABG19]
MYPSNRSLISLDELNEQNREQVEYKKGEIKTLLGSNRFQIQLPFSRAEFVTELPKKQKGMSISGYQPKLSLAINDDNQLG
VVEDKALFILKPSPEEFPHLAENEHATMLVMKFLGFDTPPFGLVRFNDPDGEGELAFMIRRYDRLNAGKEAIHQEQLDAA
MAVREKYGKTEGDAEGYVSYEQACKFLIHQVDGSLNFKKELFSRILVAYFLGNNDLHLRNIGLLLPEQEATRLAPIYDYV
SIAPYPGYIANENPLALPLLASEEGDNYNTNGYQSHSTYTGYDFLTFAQNIGLNPKLATKMIQDLCAKQEEILDIYRNSF
MLPEHVEKVAEWILSRINYLGQLEHVAV

Download         Length: 1047 bp

>T196750 NZ_CP095376:8848355-8848720 [Amycolatopsis pretoriensis]
ATGGAGTGGGAGATCGAGCTGCACGACGAGGTCGACCGGTGGTTCGTGGACCTGTGCCGGACCGACCCGGTCTCTGCGGA
CCGGGTCGAAGAGGCGATCGACGTGCTCGCTCGGGAAGGTCCCGGTCTCGGGCGGCCGCTGGTCGATCGGGTGCACGGTT
CGAGGCTGCACAACCTGAAAGAGCTGCGGCCGGCCTCTGCGGGCGCCAGCGAGATCAGGATCCTGTTCGCGTTCGACCCC
GTCCGGCGCGCGGTGCTCCTGGTCGCCGGCGACAAGGCCGGGAACTGGAAGGGTTGGTACGACCGGAACATCCCCGTCGC
GGAGCTGCGGTTTCGCGAACACCTGAGTCACGGAGCGGAGGGCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12305.13 Da        Isoelectric Point: 5.7302

>AT196750 WP_055467268.1 NZ_CP071708:c1747622-1747296 [Vibrio sp. ABG19]
MDRKVKVLLYGKFCGVLSQNEQGYLFEYEPGYRGRSLSLSMPVADGPFESKELHPFFLSLAPEGWLKKRYSELQKIDEND
PLGMLLSNGKNLLGAVQLLRLEDHVSEQ

Download         Length: 327 bp

>AT196750 NZ_CP095376:8848725-8849096 [Amycolatopsis pretoriensis]
ATGAGCCGATCCTGGAAGGACGTGAAGGCGGACAAGGCCGCCATCGACCGGGACGCCGGCCGGGACGTCGGGGGTGCTCG
GGCCGCCGCGCGCGAAGCCACCGAGGCGTTCGTGCTCGGGTTCCGCCTGGCTCAGCTCCGCGAGGACGCCGGCCTCAGCC
AGACCGAGCTCGCCAAGCGCATGGGCGTCAGCCAGCCGAGGATCAGTCAGCTCGAGCAGGGGGACCCCGGGCAGATGGAG
CTGGACACCCTGCGGCGCTACATCTCGGCTCTCGGCGGCCGGCTGCGCGTGGTCGCGGACTTCGACGACCACGACGTCAC
CGTCTCCGCTCCCGCGCCCGAGGCCGCGCCCGAGGCCGGGGCCTGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References