Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 1746266..1747622 | Replicon | chromosome |
| Accession | NZ_CP071708 | ||
| Organism | Vibrio sp. ABG19 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | - |
| Locus tag | J0X00_RS14315 | Protein ID | WP_282477073.1 |
| Coordinates | 1746266..1747312 (-) | Length | 349 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | - |
| Locus tag | J0X00_RS14320 | Protein ID | WP_055467268.1 |
| Coordinates | 1747296..1747622 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J0X00_RS14280 (J0X00_14275) | 1741984..1742346 | - | 363 | WP_282477068.1 | conjugal transfer transcriptional regulator TraJ | - |
| J0X00_RS14285 (J0X00_14280) | 1742690..1743034 | - | 345 | WP_282477069.1 | TraK family protein | - |
| J0X00_RS14290 (J0X00_14285) | 1743036..1743275 | - | 240 | WP_017048924.1 | hypothetical protein | - |
| J0X00_RS14295 (J0X00_14290) | 1744243..1745043 | + | 801 | WP_282477070.1 | TIGR02391 family protein | - |
| J0X00_RS14300 (J0X00_14295) | 1745160..1745408 | + | 249 | WP_188963142.1 | hypothetical protein | - |
| J0X00_RS14305 | 1745555..1745800 | + | 246 | WP_282477071.1 | hypothetical protein | - |
| J0X00_RS14310 (J0X00_14300) | 1746071..1746262 | - | 192 | WP_282477072.1 | hypothetical protein | - |
| J0X00_RS14315 (J0X00_14305) | 1746266..1747312 | - | 1047 | WP_282477073.1 | HipA domain-containing protein | Toxin |
| J0X00_RS14320 (J0X00_14310) | 1747296..1747622 | - | 327 | WP_055467268.1 | HipA N-terminal domain-containing protein | Antitoxin |
| J0X00_RS14325 (J0X00_14315) | 1747607..1747927 | - | 321 | WP_282477074.1 | helix-turn-helix transcriptional regulator | - |
| J0X00_RS14330 (J0X00_14320) | 1748211..1749302 | - | 1092 | WP_282477075.1 | site-specific integrase | - |
| J0X00_RS14340 (J0X00_14330) | 1749617..1751497 | - | 1881 | WP_136483291.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1710668..1757580 | 46912 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 349 a.a. Molecular weight: 39598.97 Da Isoelectric Point: 4.8085
>T196750 WP_282477073.1 NZ_CP071708:c1747312-1746266 [Vibrio sp. ABG19]
MYPSNRSLISLDELNEQNREQVEYKKGEIKTLLGSNRFQIQLPFSRAEFVTELPKKQKGMSISGYQPKLSLAINDDNQLG
VVEDKALFILKPSPEEFPHLAENEHATMLVMKFLGFDTPPFGLVRFNDPDGEGELAFMIRRYDRLNAGKEAIHQEQLDAA
MAVREKYGKTEGDAEGYVSYEQACKFLIHQVDGSLNFKKELFSRILVAYFLGNNDLHLRNIGLLLPEQEATRLAPIYDYV
SIAPYPGYIANENPLALPLLASEEGDNYNTNGYQSHSTYTGYDFLTFAQNIGLNPKLATKMIQDLCAKQEEILDIYRNSF
MLPEHVEKVAEWILSRINYLGQLEHVAV
MYPSNRSLISLDELNEQNREQVEYKKGEIKTLLGSNRFQIQLPFSRAEFVTELPKKQKGMSISGYQPKLSLAINDDNQLG
VVEDKALFILKPSPEEFPHLAENEHATMLVMKFLGFDTPPFGLVRFNDPDGEGELAFMIRRYDRLNAGKEAIHQEQLDAA
MAVREKYGKTEGDAEGYVSYEQACKFLIHQVDGSLNFKKELFSRILVAYFLGNNDLHLRNIGLLLPEQEATRLAPIYDYV
SIAPYPGYIANENPLALPLLASEEGDNYNTNGYQSHSTYTGYDFLTFAQNIGLNPKLATKMIQDLCAKQEEILDIYRNSF
MLPEHVEKVAEWILSRINYLGQLEHVAV
Download Length: 1047 bp
>T196750 NZ_CP095376:8848355-8848720 [Amycolatopsis pretoriensis]
ATGGAGTGGGAGATCGAGCTGCACGACGAGGTCGACCGGTGGTTCGTGGACCTGTGCCGGACCGACCCGGTCTCTGCGGA
CCGGGTCGAAGAGGCGATCGACGTGCTCGCTCGGGAAGGTCCCGGTCTCGGGCGGCCGCTGGTCGATCGGGTGCACGGTT
CGAGGCTGCACAACCTGAAAGAGCTGCGGCCGGCCTCTGCGGGCGCCAGCGAGATCAGGATCCTGTTCGCGTTCGACCCC
GTCCGGCGCGCGGTGCTCCTGGTCGCCGGCGACAAGGCCGGGAACTGGAAGGGTTGGTACGACCGGAACATCCCCGTCGC
GGAGCTGCGGTTTCGCGAACACCTGAGTCACGGAGCGGAGGGCTGA
ATGGAGTGGGAGATCGAGCTGCACGACGAGGTCGACCGGTGGTTCGTGGACCTGTGCCGGACCGACCCGGTCTCTGCGGA
CCGGGTCGAAGAGGCGATCGACGTGCTCGCTCGGGAAGGTCCCGGTCTCGGGCGGCCGCTGGTCGATCGGGTGCACGGTT
CGAGGCTGCACAACCTGAAAGAGCTGCGGCCGGCCTCTGCGGGCGCCAGCGAGATCAGGATCCTGTTCGCGTTCGACCCC
GTCCGGCGCGCGGTGCTCCTGGTCGCCGGCGACAAGGCCGGGAACTGGAAGGGTTGGTACGACCGGAACATCCCCGTCGC
GGAGCTGCGGTTTCGCGAACACCTGAGTCACGGAGCGGAGGGCTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12305.13 Da Isoelectric Point: 5.7302
>AT196750 WP_055467268.1 NZ_CP071708:c1747622-1747296 [Vibrio sp. ABG19]
MDRKVKVLLYGKFCGVLSQNEQGYLFEYEPGYRGRSLSLSMPVADGPFESKELHPFFLSLAPEGWLKKRYSELQKIDEND
PLGMLLSNGKNLLGAVQLLRLEDHVSEQ
MDRKVKVLLYGKFCGVLSQNEQGYLFEYEPGYRGRSLSLSMPVADGPFESKELHPFFLSLAPEGWLKKRYSELQKIDEND
PLGMLLSNGKNLLGAVQLLRLEDHVSEQ
Download Length: 327 bp
>AT196750 NZ_CP095376:8848725-8849096 [Amycolatopsis pretoriensis]
ATGAGCCGATCCTGGAAGGACGTGAAGGCGGACAAGGCCGCCATCGACCGGGACGCCGGCCGGGACGTCGGGGGTGCTCG
GGCCGCCGCGCGCGAAGCCACCGAGGCGTTCGTGCTCGGGTTCCGCCTGGCTCAGCTCCGCGAGGACGCCGGCCTCAGCC
AGACCGAGCTCGCCAAGCGCATGGGCGTCAGCCAGCCGAGGATCAGTCAGCTCGAGCAGGGGGACCCCGGGCAGATGGAG
CTGGACACCCTGCGGCGCTACATCTCGGCTCTCGGCGGCCGGCTGCGCGTGGTCGCGGACTTCGACGACCACGACGTCAC
CGTCTCCGCTCCCGCGCCCGAGGCCGCGCCCGAGGCCGGGGCCTGCGCCTGA
ATGAGCCGATCCTGGAAGGACGTGAAGGCGGACAAGGCCGCCATCGACCGGGACGCCGGCCGGGACGTCGGGGGTGCTCG
GGCCGCCGCGCGCGAAGCCACCGAGGCGTTCGTGCTCGGGTTCCGCCTGGCTCAGCTCCGCGAGGACGCCGGCCTCAGCC
AGACCGAGCTCGCCAAGCGCATGGGCGTCAGCCAGCCGAGGATCAGTCAGCTCGAGCAGGGGGACCCCGGGCAGATGGAG
CTGGACACCCTGCGGCGCTACATCTCGGCTCTCGGCGGCCGGCTGCGCGTGGTCGCGGACTTCGACGACCACGACGTCAC
CGTCTCCGCTCCCGCGCCCGAGGCCGCGCCCGAGGCCGGGGCCTGCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|