196749

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1722160..1723516 Replicon chromosome
Accession NZ_CP071708
Organism Vibrio sp. ABG19

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag J0X00_RS14180 Protein ID WP_282477050.1
Coordinates 1722160..1723206 (-) Length 349 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag J0X00_RS14185 Protein ID WP_282477051.1
Coordinates 1723190..1723516 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0X00_RS14155 (J0X00_14150) 1717520..1717999 + 480 WP_282477046.1 TRAP transporter small permease -
J0X00_RS14160 (J0X00_14155) 1718004..1719290 + 1287 WP_282477047.1 TRAP transporter large permease -
J0X00_RS14165 (J0X00_14160) 1719400..1720101 + 702 WP_282477048.1 FadR/GntR family transcriptional regulator -
J0X00_RS14170 (J0X00_14165) 1720177..1721430 + 1254 WP_282477049.1 enolase C-terminal domain-like protein -
J0X00_RS14175 (J0X00_14170) 1721527..1721637 + 111 Protein_1479 integrase core domain-containing protein -
J0X00_RS14180 (J0X00_14175) 1722160..1723206 - 1047 WP_282477050.1 HipA domain-containing protein Toxin
J0X00_RS14185 (J0X00_14180) 1723190..1723516 - 327 WP_282477051.1 HipA N-terminal domain-containing protein Antitoxin
J0X00_RS14190 (J0X00_14185) 1723501..1723821 - 321 WP_282477052.1 helix-turn-helix transcriptional regulator -
J0X00_RS14195 (J0X00_14190) 1724009..1725415 - 1407 WP_282477053.1 HipA domain-containing protein -
J0X00_RS14200 (J0X00_14195) 1725408..1725743 - 336 WP_282477054.1 helix-turn-helix domain-containing protein -
J0X00_RS14205 (J0X00_14200) 1726448..1726912 + 465 WP_282477055.1 hypothetical protein -
J0X00_RS14210 (J0X00_14205) 1727188..1727598 - 411 WP_218562344.1 hypothetical protein -
J0X00_RS14215 (J0X00_14210) 1727671..1728033 + 363 WP_282477056.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1710668..1757580 46912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(60-309)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 349 a.a.        Molecular weight: 39507.95 Da        Isoelectric Point: 5.0366

>T196749 WP_282477050.1 NZ_CP071708:c1723206-1722160 [Vibrio sp. ABG19]
MYPSNRSLISLDELNEQNREQVEYKKGEIKTLLGSNRFQIHLPFSRAEFVTELPKKQKGMSISGYQPKLSLAINDDNQLG
VVENKALFILKPSPEEFPHLAENEHATMLVMKFLGFDTPPFGLVRFNDPNGEGELAFMIRRYDRLNAGEEAIHQEQLDAA
MAVQEKYGKTEGDAKGYVSYEQACKFLIHQVDGSLNFKKELFNRILVAYFLGNNDLNLRNIGLLLPEQEATRLAPIYDYV
SIAPYPGYIANENPLALPLLASEEGDNFNTSGYQSHSTYTGYDFLTFAQNIGLNPKLATKMIKDLCAKQEAILDIYRNSF
MLPEHVEKVAEWILNRINYLGQLEHVAV

Download         Length: 1047 bp

>T196749 NZ_CP095284:15120-15470 [Aeromonas hydrophila]
ATGTGGACAGTAAAAACGACCGATCTGTTTGATACTTGGTTCGACGCACAAGACGATGCGACACAGGAAAAGGTCTTGGC
CGGGTTGCTGGCTTTGGCACAGGGTGGCCCATCGGTAGGGCGCCCTTTGGTTGATACCATTAAGGGCTCCAGCTTTACGA
ACCTCAAAGAGCTGAGGGTTCAGCACCAAGGGGAACCACTGCGGGCCTTCTTCGCCTTTGATCCGTTACGACAAGCAATC
GTGCTGTGCGCCGGCAATAAGGGCGGTAACGAGAAGAGGTTTTACAAAGAAATGTTGCCGATTGCTGAGGCTGAATACGC
TAGGCATTTAGCTGAATTGGAGATGCGATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12319.16 Da        Isoelectric Point: 5.7425

>AT196749 WP_282477051.1 NZ_CP071708:c1723516-1723190 [Vibrio sp. ABG19]
MDRKVKVLLYGKFCGVLSQNEQGYLFEYEPGYRGRSLSLSMPVEGGPFESKELHPFFLSLAPEGWLKKRYSELQKIDEND
PLGMLLSNGKNLLGAVQLLRLEEHVSEQ

Download         Length: 327 bp

>AT196749 NZ_CP095284:15470-15772 [Aeromonas hydrophila]
ATGGGAAAAACACTGACTGAAATGCTAGCCTCCCGCTCGGAGGATAGCCAGCAACGTATCAAGGATATGGCTGACGAACT
GATGCTGGAAGTACGCTTGCAAGCTGTGCGCGAAGAGCTAGAGGTCTCCCAGGTGGAATTAGCCTCAGCACTCGGTATTA
CACAGCCAGCTATTGTGAAGTTGGAGCAACGCGGTAGCGATGTCAAACTATCCACAATGAAGCGCTACGTGGAGGCTATG
GGTGGAAAGCTGCGTGTGGATGTAGAGCTTCCAACGGGACGACATATTGGTTTCAACGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References