Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2231068..2231587 Replicon chromosome
Accession NZ_CP071697
Organism Streptococcus suis strain 1112S

Toxin (Protein)


Gene name yoeB Uniprot ID A0A116LVN8
Locus tag J1N58_RS10590 Protein ID WP_029176515.1
Coordinates 2231068..2231325 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M9FLP3
Locus tag J1N58_RS10595 Protein ID WP_029693536.1
Coordinates 2231327..2231587 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1N58_RS10575 2227700..2229430 - 1731 WP_207560352.1 hypothetical protein -
J1N58_RS10580 2229632..2230540 - 909 WP_079267516.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
J1N58_RS10585 2230524..2231054 - 531 WP_029176516.1 DUF1697 domain-containing protein -
J1N58_RS10590 2231068..2231325 - 258 WP_029176515.1 Txe/YoeB family addiction module toxin Toxin
J1N58_RS10595 2231327..2231587 - 261 WP_029693536.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J1N58_RS10600 2231663..2232118 - 456 WP_207560353.1 NUDIX domain-containing protein -
J1N58_RS10605 2232125..2232454 - 330 WP_024376095.1 type II toxin-antitoxin system RelE/ParE family toxin -
J1N58_RS10610 2232444..2232731 - 288 WP_024376096.1 hypothetical protein -
J1N58_RS10615 2232829..2233197 - 369 WP_207560354.1 hypothetical protein -
J1N58_RS10620 2233190..2233759 - 570 WP_207560355.1 ribonuclease M5 -
J1N58_RS10625 2233743..2234525 - 783 WP_207560356.1 YchF/TatD family DNA exonuclease -
J1N58_RS10630 2234610..2234747 - 138 WP_002939016.1 50S ribosomal protein L34 -
J1N58_RS10635 2234915..2235910 - 996 WP_002940330.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10290.79 Da        Isoelectric Point: 8.0279

>T196737 WP_029176515.1 NZ_CP071697:c2231325-2231068 [Streptococcus suis]
MGIHFTEDAWEDYLYWQSQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEANRLCILSL
KDHYG

Download         Length: 258 bp

>T196737 NZ_CP095276:c2992845-2992492 [Enterobacter hormaechei subsp. xiangfangensis]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.29 Da        Isoelectric Point: 5.1255

>AT196737 WP_029693536.1 NZ_CP071697:c2231587-2231327 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp

>AT196737 NZ_CP095276:c2992487-2992185 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTTCGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A116LVN8

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FLP3

References