Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4489813..4490567 Replicon chromosome
Accession NZ_CP071693
Organism Salmonella sp. SAL-045

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag J1G49_RS21705 Protein ID WP_000558168.1
Coordinates 4489813..4490124 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J1G49_RS21710 Protein ID WP_001259009.1
Coordinates 4490121..4490567 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G49_RS21675 4485471..4486373 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
J1G49_RS21680 4486370..4487005 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
J1G49_RS21685 4487002..4487931 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
J1G49_RS21690 4487978..4488268 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
J1G49_RS21695 4488269..4488580 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
J1G49_RS21700 4488798..4489727 + 930 WP_001127705.1 alpha/beta hydrolase -
J1G49_RS21705 4489813..4490124 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
J1G49_RS21710 4490121..4490567 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
J1G49_RS21715 4490582..4491523 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
J1G49_RS21720 4491568..4492005 - 438 WP_000560968.1 D-tyrosyl-tRNA(Tyr) deacylase -
J1G49_RS21725 4492002..4492874 - 873 WP_000921423.1 virulence factor BrkB family protein -
J1G49_RS21730 4492868..4493467 - 600 WP_000965695.1 glucose-1-phosphatase -
J1G49_RS21735 4493658..4494461 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
J1G49_RS21740 4494495..4495391 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T196728 WP_000558168.1 NZ_CP071693:4489813-4490124 [Salmonella sp. SAL-045]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T196728 NZ_CP095272:98544-98693 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT196728 WP_001259009.1 NZ_CP071693:4490121-4490567 [Salmonella sp. SAL-045]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT196728 NZ_CP095272:c98500-98439 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2S541

Antitoxin

Source ID Structure

References