Detailed information of TA system TA196683

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443975..2444200
• Replicon: chromosome
• Accession: NZ_CP071690
• Organism: Salmonella sp. SAL-020

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: J1G48_RS11815
• Protein ID: WP_000813254.1
• Coordinates: 2443975..2444130 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2444142..2444200 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1G48_RS11780	2439082..2439363	-	282	WP_000445513.1	phage holin family protein	-
J1G48_RS11785	2439353..2439541	-	189	WP_001688615.1	hypothetical protein	-
J1G48_RS11790	2439535..2439858	-	324	Protein_2308	tellurite resistance TerB family protein	-
J1G48_RS11795	2442029..2442565	-	537	WP_000640113.1	DUF1133 family protein	-
J1G48_RS11800	2442562..2442852	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
J1G48_RS11805	2442852..2443451	-	600	WP_000940751.1	DUF1367 family protein	-
J1G48_RS11810	2443514..2443684	-	171	WP_000734094.1	hypothetical protein	-
J1G48_RS11815	2443975..2444130	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2444142..2444200	+	59	-	-	Antitoxin
J1G48_RS11820	2444557..2445489	+	933	WP_000556390.1	hypothetical protein	-
J1G48_RS11825	2445486..2446040	+	555	WP_001033796.1	hypothetical protein	-
J1G48_RS11830	2446202..2446531	-	330	WP_001676916.1	DUF977 family protein	-
J1G48_RS11835	2446515..2446700	-	186	Protein_2317	helix-turn-helix domain-containing protein	-
J1G48_RS11840	2446804..2447271	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
J1G48_RS11845	2447656..2447811	+	156	WP_085981757.1	DUF1391 family protein	-
J1G48_RS11850	2447919..2448440	-	522	WP_000004762.1	superinfection exclusion B family protein	-
J1G48_RS11855	2448878..2449099	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438540..2450411	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T196683 WP_000813254.1 NZ_CP071690:c2444130-2443975 [Salmonella sp. SAL-020]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T196683 NZ_CP095255:55680-55991 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT196683 NZ_CP071690:2444142-2444200 [Salmonella sp. SAL-020]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin