Detailed information of TA system TA196657

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443720..2443945
• Replicon: chromosome
• Accession: NZ_CP071686
• Organism: Salmonella sp. SAL-007

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: J1G46_RS11820
• Protein ID: WP_000813254.1
• Coordinates: 2443720..2443875 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2443887..2443945 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1G46_RS11785	2438827..2439108	-	282	WP_000445513.1	phage holin family protein	-
J1G46_RS11790	2439098..2439286	-	189	WP_001688615.1	hypothetical protein	-
J1G46_RS11795	2439280..2439603	-	324	Protein_2309	tellurite resistance TerB family protein	-
J1G46_RS11800	2441774..2442310	-	537	WP_000640113.1	DUF1133 family protein	-
J1G46_RS11805	2442307..2442597	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
J1G46_RS11810	2442597..2443196	-	600	WP_000940751.1	DUF1367 family protein	-
J1G46_RS11815	2443259..2443429	-	171	WP_000734094.1	hypothetical protein	-
J1G46_RS11820	2443720..2443875	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2443887..2443945	+	59	-	-	Antitoxin
J1G46_RS11825	2444302..2445234	+	933	WP_000556390.1	hypothetical protein	-
J1G46_RS11830	2445231..2445785	+	555	WP_001033796.1	hypothetical protein	-
J1G46_RS11835	2445947..2446276	-	330	WP_001676916.1	DUF977 family protein	-
J1G46_RS11840	2446260..2446445	-	186	Protein_2318	helix-turn-helix domain-containing protein	-
J1G46_RS11845	2446549..2447016	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
J1G46_RS11850	2447401..2447556	+	156	WP_085981757.1	DUF1391 family protein	-
J1G46_RS11855	2447664..2448185	-	522	WP_000004762.1	superinfection exclusion B family protein	-
J1G46_RS11860	2448623..2448844	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438285..2450156	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T196657 WP_000813254.1 NZ_CP071686:c2443875-2443720 [Salmonella sp. SAL-007]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T196657 NZ_CP095247:744219-744704 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT196657 NZ_CP071686:2443887-2443945 [Salmonella sp. SAL-007]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin