Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 71429..71951 Replicon plasmid p2
Accession NZ_CP071628
Organism Rhizobium leguminosarum strain GLR17

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag J3P71_RS29555 Protein ID WP_168305687.1
Coordinates 71682..71951 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A6N9ZA60
Locus tag J3P71_RS29550 Protein ID WP_017968209.1
Coordinates 71429..71680 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P71_RS29540 67996..69339 - 1344 WP_026265592.1 adenylate/guanylate cyclase domain-containing protein -
J3P71_RS29545 69957..71294 + 1338 WP_168305686.1 nucleotide sugar dehydrogenase -
J3P71_RS29550 71429..71680 + 252 WP_017968209.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J3P71_RS29555 71682..71951 + 270 WP_168305687.1 Txe/YoeB family addiction module toxin Toxin
J3P71_RS29560 72006..73232 - 1227 WP_168305688.1 DUF3095 domain-containing protein -
J3P71_RS29565 73406..73885 + 480 WP_168305689.1 hypothetical protein -
J3P71_RS29570 73910..75700 - 1791 WP_020052934.1 ABC transporter ATP-binding protein/permease -
J3P71_RS29575 76084..76539 - 456 WP_168305690.1 Rrf2 family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..538250 538250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10753.38 Da        Isoelectric Point: 9.4684

>T196632 WP_168305687.1 NZ_CP071628:71682-71951 [Rhizobium leguminosarum]
MKLLWTPNSWEEYEYWQRNDHKMVEKINELLKDTKRSPFKGLGKPEPLKGDLSGFWSRRILGEHRLVYCVTGKGNQQLEI
IQCRFHYEK

Download         Length: 270 bp

>T196632 NZ_CP095234:4392426-4392528 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9273.53 Da        Isoelectric Point: 5.6513

>AT196632 WP_017968209.1 NZ_CP071628:71429-71680 [Rhizobium leguminosarum]
MAHVRLTEFRQNIATYFDQVLSSRAPLLVTRQGSEAMVLVAEGEYESMQETLHLLSTPANSARLRESIGQLRKGQVVESD
PTL

Download         Length: 252 bp

>AT196632 NZ_CP095234:c4392535-4392390 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6N9ZA60

References