Detailed information of TA system TA196602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1806035..1806648
• Replicon: chromosome
• Accession: NZ_CP071602
• Organism: Bordetella parapertussis strain CIDM-BPP2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: J3Q23_RS08350
• Protein ID: WP_003811545.1
• Coordinates: 1806337..1806648 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: J3Q23_RS08345
• Protein ID: WP_003811547.1
• Coordinates: 1806035..1806334 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3Q23_RS08335	1802626..1803300	-	675	WP_010928712.1	response regulator transcription factor	-
J3Q23_RS08340	1803430..1806021	+	2592	WP_065956700.1	autotransporter domain-containing protein	-
J3Q23_RS08345	1806035..1806334	-	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
J3Q23_RS08350	1806337..1806648	-	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J3Q23_RS08355	1806762..1807385	-	624	WP_003811542.1	glutathione S-transferase family protein	-
J3Q23_RS08360	1807504..1808457	-	954	WP_041937234.1	LysR family transcriptional regulator	-
J3Q23_RS08365	1808574..1809536	+	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
J3Q23_RS08370	1809551..1810945	+	1395	WP_003811536.1	arylsulfatase	-
J3Q23_RS08375	1810942..1811496	+	555	Protein_1652	LamB/YcsF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T196602 WP_003811545.1 NZ_CP071602:c1806648-1806337 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T196602 NZ_CP095177:c2784894-2784791 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT196602 WP_003811547.1 NZ_CP071602:c1806334-1806035 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT196602 NZ_CP095177:2784784-2784987 [Enterobacter hormaechei]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTG
GTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Structures

Toxin

• AlphaFold DB: K0MEM3