Detailed information of TA system TA196599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1974543..1975198
• Replicon: chromosome
• Accession: NZ_CP071601
• Organism: Bordetella pertussis strain CIDM-BP5

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: J3Q25_RS09545
• Protein ID: WP_047122780.1
• Coordinates: 1974543..1974794 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: J3Q25_RS09550
• Protein ID: WP_003809516.1
• Coordinates: 1974797..1975198 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3Q25_RS09520	1969704..1970834	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
J3Q25_RS09525	1971069..1971650	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
J3Q25_RS09530	1971787..1972851	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
J3Q25_RS09535	1972936..1973382	-	447	WP_003819827.1	GFA family protein	-
J3Q25_RS09540	1973607..1974488	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
J3Q25_RS09545	1974543..1974794	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
J3Q25_RS09550	1974797..1975198	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
J3Q25_RS09555	1975218..1975454	+	237	WP_010930404.1	membrane protein	-
J3Q25_RS09560	1975462..1975941	+	480	WP_010930405.1	disulfide bond formation protein B	-
J3Q25_RS09565	1976091..1976606	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
J3Q25_RS09570	1976609..1977799	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
J3Q25_RS09575	1977819..1978856	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
J3Q25_RS09580	1978993..1980015	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T196599 WP_047122780.1 NZ_CP071601:1974543-1974794 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T196599 NZ_CP095177:c292552-292250 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT196599 WP_003809516.1 NZ_CP071601:1974797-1975198 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT196599 NZ_CP095177:c292243-291956 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6