Detailed information of TA system TA196593

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2704053..2704233
• Replicon: chromosome
• Accession: NZ_CP071594
• Organism: Staphylococcus aureus strain PNID0137

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: J3R87_RS13225
• Protein ID: WP_001801861.1
• Coordinates: 2704053..2704148 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2704176..2704233 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3R87_RS13195	2699197..2699823	+	627	WP_000669038.1	hypothetical protein	-
J3R87_RS13200	2699864..2700208	+	345	WP_213674488.1	DUF3969 family protein	-
J3R87_RS13205	2700306..2700878	+	573	WP_000414222.1	hypothetical protein	-
J3R87_RS13210	2701027..2702394	-	1368	WP_213674489.1	FRG domain-containing protein	-
J3R87_RS13215	2702394..2702963	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
J3R87_RS13220	2703156..2703602	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
J3R87_RS13225	2704053..2704148	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2704176..2704233	-	58	-	-	Antitoxin
J3R87_RS13230	2704271..2704372	+	102	WP_001791232.1	hypothetical protein	-
J3R87_RS13235	2704547..2704990	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
J3R87_RS13240	2704990..2705433	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
J3R87_RS13245	2705433..2705875	-	443	Protein_2619	DUF1433 domain-containing protein	-
J3R87_RS13250	2706400..2708819	+	2420	Protein_2620	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / hysA / selk	2696638..2733995	37357

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T196593 WP_001801861.1 NZ_CP071594:2704053-2704148 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T196593 NZ_CP095170:c4043445-4043035 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGCGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT196593 NZ_CP071594:c2704233-2704176 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin