Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2332095..2332394 Replicon chromosome
Accession NZ_CP071594
Organism Staphylococcus aureus strain PNID0137

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag J3R87_RS11275 Protein ID WP_011447039.1
Coordinates 2332218..2332394 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2332095..2332152 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R87_RS11240 2327567..2328472 - 906 WP_000913238.1 DUF1672 domain-containing protein -
J3R87_RS11245 2328562..2328777 - 216 WP_170267452.1 hypothetical protein -
J3R87_RS11250 2328982..2329719 - 738 WP_000278830.1 hypothetical protein -
J3R87_RS11255 2329726..2330520 - 795 WP_000238963.1 phosphatidylinositol kinase -
J3R87_RS11260 2330985..2331740 - 756 WP_000861038.1 CHAP domain-containing protein -
J3R87_RS11265 2331752..2332006 - 255 WP_000611512.1 phage holin -
J3R87_RS11270 2332058..2332165 + 108 WP_031790389.1 hypothetical protein -
- 2332087..2332226 + 140 NuclAT_0 - -
- 2332087..2332226 + 140 NuclAT_0 - -
- 2332087..2332226 + 140 NuclAT_0 - -
- 2332087..2332226 + 140 NuclAT_0 - -
- 2332095..2332152 + 58 - - Antitoxin
J3R87_RS11275 2332218..2332394 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
J3R87_RS11280 2332544..2332840 - 297 WP_000539688.1 DUF2951 domain-containing protein -
J3R87_RS11285 2332898..2333185 - 288 WP_001040261.1 hypothetical protein -
J3R87_RS11290 2333232..2333384 - 153 WP_001153681.1 hypothetical protein -
J3R87_RS11295 2333374..2337159 - 3786 WP_073392894.1 phage tail spike protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ebp 2321011..2380992 59981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T196591 WP_011447039.1 NZ_CP071594:c2332394-2332218 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T196591 NZ_CP095170:c2943045-2942942 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT196591 NZ_CP071594:2332095-2332152 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References