Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 5761159..5761814 Replicon chromosome
Accession NZ_CP071586
Organism Pseudomonas germanica strain FIT28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J0G10_RS25440 Protein ID WP_220556965.1
Coordinates 5761470..5761814 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J0G10_RS25435 Protein ID WP_127929687.1
Coordinates 5761159..5761473 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G10_RS25410 (J0G10_25430) 5757241..5758146 + 906 WP_220556963.1 LysR family transcriptional regulator -
J0G10_RS25415 (J0G10_25435) 5758203..5758607 + 405 WP_077574458.1 GNAT family N-acetyltransferase -
J0G10_RS25420 (J0G10_25440) 5758668..5759183 + 516 WP_220556964.1 hypothetical protein -
J0G10_RS30085 5759223..5759387 + 165 Protein_5031 ATP-binding protein -
J0G10_RS25425 (J0G10_25445) 5759505..5760206 + 702 WP_007949995.1 hypothetical protein -
J0G10_RS25430 (J0G10_25450) 5760467..5760958 - 492 WP_034156086.1 RidA family protein -
J0G10_RS25435 (J0G10_25455) 5761159..5761473 - 315 WP_127929687.1 helix-turn-helix domain-containing protein Antitoxin
J0G10_RS25440 (J0G10_25460) 5761470..5761814 - 345 WP_220556965.1 toxin Toxin
J0G10_RS25445 (J0G10_25465) 5761930..5762817 - 888 WP_007916939.1 heme o synthase -
J0G10_RS25450 (J0G10_25470) 5762829..5763164 - 336 WP_007916940.1 cytochrome o ubiquinol oxidase subunit IV -
J0G10_RS25455 (J0G10_25475) 5763164..5763787 - 624 WP_034156084.1 cytochrome o ubiquinol oxidase subunit III -
J0G10_RS25460 (J0G10_25480) 5763791..5765821 - 2031 WP_007916945.1 cytochrome o ubiquinol oxidase subunit I -
J0G10_RS25465 (J0G10_25485) 5765825..5766766 - 942 WP_007916947.1 ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-94)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13278.18 Da        Isoelectric Point: 9.8527

>T196571 WP_220556965.1 NZ_CP071586:c5761814-5761470 [Pseudomonas germanica]
MRTVFFETTIFTTSVGHYLTDDEYRELQAYMQGNPLAGDVMPRTGGFRKLRWADARRGKGRRGGLRVIYYWLMNDGQFWM
FAIYDKDGLENLTAEQEKALKKAIDKELKTRGTP

Download         Length: 345 bp

>T196571 NZ_CP095163:c2024398-2024117 [Edwardsiella anguillarum]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCGCCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATTATCCTGCTGGTGATCGCGATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11813.79 Da        Isoelectric Point: 10.2425

>AT196571 WP_127929687.1 NZ_CP071586:c5761473-5761159 [Pseudomonas germanica]
MKKRDLFAELMQGVDEMAAQREGKITLRNTVLEDKPVPEVGAQEIVALREKLHMSQAVFAKRIRASPSTLRNWEQEKSKP
NAQAALLIRLVEKFPDMVDRLSAV

Download         Length: 315 bp

>AT196571 NZ_CP095163:c2024639-2024388 [Edwardsiella anguillarum]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGCAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCACTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References