Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 3679261..3679955 | Replicon | chromosome |
Accession | NZ_CP071521 | ||
Organism | Escherichia coli strain 11202 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | Q47157 |
Locus tag | J2D70_RS18055 | Protein ID | WP_001263489.1 |
Coordinates | 3679261..3679659 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | S1QAE3 |
Locus tag | J2D70_RS18060 | Protein ID | WP_000554758.1 |
Coordinates | 3679662..3679955 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
- (3674849) | 3674849..3674929 | - | 81 | NuclAT_12 | - | - |
- (3674849) | 3674849..3674929 | - | 81 | NuclAT_12 | - | - |
- (3674849) | 3674849..3674929 | - | 81 | NuclAT_12 | - | - |
- (3674849) | 3674849..3674929 | - | 81 | NuclAT_12 | - | - |
J2D70_RS18030 (3675525) | 3675525..3675983 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
J2D70_RS18035 (3676244) | 3676244..3677701 | + | 1458 | WP_001292994.1 | cytosol nonspecific dipeptidase | - |
J2D70_RS18040 (3677758) | 3677758..3678279 | - | 522 | Protein_3552 | peptide chain release factor H | - |
J2D70_RS18045 (3678275) | 3678275..3678481 | - | 207 | Protein_3553 | RtcB family protein | - |
J2D70_RS18050 (3678799) | 3678799..3679251 | - | 453 | WP_001059892.1 | GNAT family N-acetyltransferase | - |
J2D70_RS18055 (3679261) | 3679261..3679659 | - | 399 | WP_001263489.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
J2D70_RS18060 (3679662) | 3679662..3679955 | - | 294 | WP_000554758.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
J2D70_RS18065 (3680007) | 3680007..3681062 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
J2D70_RS18070 (3681133) | 3681133..3681918 | - | 786 | WP_000207552.1 | putative lateral flagellar export/assembly protein LafU | - |
J2D70_RS18075 (3681890) | 3681890..3683602 | + | 1713 | Protein_3559 | flagellar biosynthesis protein FlhA | - |
J2D70_RS18080 (3683826) | 3683826..3684323 | - | 498 | WP_000006255.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15487.84 Da Isoelectric Point: 7.4215
>T196529 WP_001263489.1 NZ_CP071521:c3679659-3679261 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T196529 NZ_CP095155:220762-220869 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.76 Da Isoelectric Point: 5.2170
>AT196529 WP_000554758.1 NZ_CP071521:c3679955-3679662 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT196529 NZ_CP095155:c220714-220648 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A090J8B1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | S1QAE3 |