196509

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 715194..715887 Replicon chromosome
Accession NZ_CP071521
Organism Escherichia coli strain 11202

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag J2D70_RS03475 Protein ID WP_000415584.1
Coordinates 715194..715490 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J2D70_RS03480 Protein ID WP_000650107.1
Coordinates 715492..715887 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J2D70_RS03440 (710282) 710282..710596 - 315 WP_000958598.1 putative quinol monooxygenase -
J2D70_RS03445 (710627) 710627..711208 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
J2D70_RS03450 (711527) 711527..711859 + 333 WP_000917684.1 DUF2645 family protein -
J2D70_RS03455 (711905) 711905..713254 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
J2D70_RS03460 (713251) 713251..713910 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
J2D70_RS03465 (714062) 714062..714454 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J2D70_RS03470 (714507) 714507..714989 + 483 WP_000183505.1 GyrI-like domain-containing protein -
J2D70_RS03475 (715194) 715194..715490 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
J2D70_RS03480 (715492) 715492..715887 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J2D70_RS03485 (716020) 716020..717627 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
J2D70_RS03490 (717765) 717765..720023 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T196509 WP_000415584.1 NZ_CP071521:715194-715490 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T196509 NZ_CP095145:c4694358-4694074 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT196509 WP_000650107.1 NZ_CP071521:715492-715887 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT196509 NZ_CP095145:c4694590-4694348 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References