Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1293745..1294388 Replicon chromosome
Accession NZ_CP071491
Organism Glaesserella parasuis strain GHP1807

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J1G54_RS06510 Protein ID WP_021109713.1
Coordinates 1294044..1294388 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J1G54_RS06505 Protein ID WP_012621770.1
Coordinates 1293745..1294041 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G54_RS06480 1288819..1289445 - 627 WP_160421926.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -
J1G54_RS06485 1289758..1290546 + 789 WP_005714049.1 SDR family oxidoreductase -
J1G54_RS06490 1290663..1291085 - 423 WP_043894462.1 helix-turn-helix transcriptional regulator -
J1G54_RS06495 1291232..1292296 + 1065 WP_071610276.1 DUF3944 domain-containing protein -
J1G54_RS06500 1292367..1293575 - 1209 WP_016527735.1 IS256 family transposase -
J1G54_RS06505 1293745..1294041 - 297 WP_012621770.1 helix-turn-helix domain-containing protein Antitoxin
J1G54_RS06510 1294044..1294388 - 345 WP_021109713.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G54_RS06515 1294603..1296582 + 1980 WP_203399278.1 exoribonuclease II -
J1G54_RS06520 1296693..1297784 + 1092 WP_005714201.1 murein transglycosylase A -
J1G54_RS06525 1297967..1298563 - 597 WP_075604519.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1292367..1293575 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(47-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13262.28 Da        Isoelectric Point: 7.9640

>T196488 WP_021109713.1 NZ_CP071491:c1294388-1294044 [Glaesserella parasuis]
METEEYLTFIKTKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T196488 NZ_CP095137:c4486555-4486382 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11224.13 Da        Isoelectric Point: 10.0887

>AT196488 WP_012621770.1 NZ_CP071491:c1294041-1293745 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPNLVPVLQNL

Download         Length: 297 bp

>AT196488 NZ_CP095137:c4486879-4486583 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References