Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 525128..525778 Replicon chromosome
Accession NZ_CP071491
Organism Glaesserella parasuis strain GHP1807

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J1G54_RS02965 Protein ID WP_160436559.1
Coordinates 525440..525778 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J1G54_RS02960 Protein ID WP_005710405.1
Coordinates 525128..525436 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G54_RS02940 521602..522090 - 489 WP_005710400.1 transcription elongation factor GreB -
J1G54_RS02945 522090..523025 - 936 WP_021110391.1 KpsF/GutQ family sugar-phosphate isomerase -
J1G54_RS02950 523086..523667 - 582 WP_005710402.1 type IV pilus biogenesis/stability protein PilW -
J1G54_RS02955 523767..524927 - 1161 WP_010786053.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
J1G54_RS02960 525128..525436 - 309 WP_005710405.1 helix-turn-helix domain-containing protein Antitoxin
J1G54_RS02965 525440..525778 - 339 WP_160436559.1 toxin Toxin
J1G54_RS02990 526618..528057 + 1440 WP_160414413.1 glutamate--tRNA ligase -
J1G54_RS03000 528524..528790 - 267 Protein_569 cation-transporting ATPase PacS -
J1G54_RS03005 528745..529654 - 910 Protein_570 transposase -
J1G54_RS03010 529775..530149 - 375 WP_021111694.1 cytochrome b562 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - msbA 466269..534077 67808
- flank IS/Tn - - 529115..529654 539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-86)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13215.26 Da        Isoelectric Point: 9.8649

>T196484 WP_160436559.1 NZ_CP071491:c525778-525440 [Glaesserella parasuis]
MNVAFVELPPFEEYRKKYLDDDSFRLLQNELLKFPDKGELIQGTGGLRKLRIVDIIRQKGKRGGARVIYYYYVRGKQVWL
FHAYNKNQQDDLSNEELVVLANTLSYLKSLVR

Download         Length: 339 bp

>T196484 NZ_CP095137:c4035697-4035383 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11539.61 Da        Isoelectric Point: 10.2919

>AT196484 WP_005710405.1 NZ_CP071491:c525436-525128 [Glaesserella parasuis]
MGKLFNELMEGMQALELHLQGKITLKTTVVEVPDPIVITPEEVKAIRQKLNLSQAVFARKLHTSVRTYQGWEQGRTKPNP
QAVLLLKMVEKSPKTFEQIASI

Download         Length: 309 bp

>AT196484 NZ_CP095137:c4035933-4035700 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References