Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1069855..1070416 Replicon chromosome
Accession NZ_CP071489
Organism Glaesserella parasuis strain YHP1815

Toxin (Protein)


Gene name higB Uniprot ID A0A143CE91
Locus tag J1G50_RS05405 Protein ID WP_005712614.1
Coordinates 1070138..1070416 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag J1G50_RS05400 Protein ID WP_005712616.1
Coordinates 1069855..1070127 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G50_RS05385 1066378..1066920 + 543 WP_021115958.1 single-stranded DNA-binding protein -
J1G50_RS05390 1067074..1068561 - 1488 WP_207356856.1 DUF853 family protein -
J1G50_RS05395 1068571..1069791 - 1221 WP_160405614.1 ATP-dependent RNA helicase RhlB -
J1G50_RS05400 1069855..1070127 - 273 WP_005712616.1 HigA family addiction module antidote protein Antitoxin
J1G50_RS05405 1070138..1070416 - 279 WP_005712614.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G50_RS05410 1070565..1071575 + 1011 WP_005712612.1 ornithine carbamoyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10326.71 Da        Isoelectric Point: 10.0505

>T196469 WP_005712614.1 NZ_CP071489:c1070416-1070138 [Glaesserella parasuis]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKFQN
GHAEVVDYQDYH

Download         Length: 279 bp

>T196469 NZ_CP095137:235756-235863 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.06 Da        Isoelectric Point: 9.8982

>AT196469 WP_005712616.1 NZ_CP071489:c1070127-1069855 [Glaesserella parasuis]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA

Download         Length: 273 bp

>AT196469 NZ_CP095137:c235699-235642 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143CE91

Antitoxin

Source ID Structure

References