Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 972132..972775 Replicon chromosome
Accession NZ_CP071489
Organism Glaesserella parasuis strain YHP1815

Toxin (Protein)


Gene name higB Uniprot ID U4SMB1
Locus tag J1G50_RS04950 Protein ID WP_005714197.1
Coordinates 972132..972476 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J1G50_RS04955 Protein ID WP_012621770.1
Coordinates 972479..972775 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G50_RS04935 967846..968474 - 629 Protein_954 transposase -
J1G50_RS04940 968737..969828 - 1092 WP_005714201.1 murein transglycosylase A -
J1G50_RS04945 969938..971917 - 1980 WP_164689528.1 exoribonuclease II -
J1G50_RS04950 972132..972476 + 345 WP_005714197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G50_RS04955 972479..972775 + 297 WP_012621770.1 helix-turn-helix domain-containing protein Antitoxin
J1G50_RS04960 972988..974196 + 1209 WP_082259179.1 IS256 family transposase -
J1G50_RS04965 974156..975289 - 1134 WP_207356844.1 DUF3944 domain-containing protein -
J1G50_RS04970 975436..975858 + 423 WP_043894462.1 helix-turn-helix transcriptional regulator -
J1G50_RS04975 975975..976763 - 789 WP_021117032.1 SDR family oxidoreductase -
J1G50_RS04980 977006..977632 + 627 WP_016527816.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 953254..1017717 64463
- flank IS/Tn - - 972988..974196 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(52-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13263.22 Da        Isoelectric Point: 5.9233

>T196468 WP_005714197.1 NZ_CP071489:972132-972476 [Glaesserella parasuis]
METEEYLTFIETKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T196468 NZ_CP095137:235273-235380 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11224.13 Da        Isoelectric Point: 10.0887

>AT196468 WP_012621770.1 NZ_CP071489:972479-972775 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPNLVPVLQNL

Download         Length: 297 bp

>AT196468 NZ_CP095137:c235224-235159 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SMB1

Antitoxin

Source ID Structure

References