Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1334637..1335279 Replicon chromosome
Accession NZ_CP071487
Organism Glaesserella parasuis strain YHP1818

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J1G47_RS06660 Protein ID WP_207326524.1
Coordinates 1334914..1335279 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J1G47_RS06655 Protein ID WP_021115782.1
Coordinates 1334637..1334933 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G47_RS06630 1329967..1330215 - 249 WP_075592723.1 hypothetical protein -
J1G47_RS06635 1330178..1332106 - 1929 WP_021119093.1 ATP-dependent zinc metalloprotease FtsH -
J1G47_RS06640 1332180..1332806 - 627 WP_160427610.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -
J1G47_RS06645 1333049..1333837 + 789 WP_005714049.1 SDR family oxidoreductase -
J1G47_RS06650 1333917..1334579 + 663 WP_160415330.1 Fic family protein -
J1G47_RS06655 1334637..1334933 - 297 WP_021115782.1 helix-turn-helix domain-containing protein Antitoxin
J1G47_RS06660 1334914..1335279 - 366 WP_207326524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1G47_RS06665 1335421..1336518 - 1098 WP_207326525.1 ISAs1 family transposase -
J1G47_RS06670 1336709..1338688 + 1980 WP_207326526.1 exoribonuclease II -
J1G47_RS06675 1338799..1339890 + 1092 WP_207326527.1 murein transglycosylase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(52-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-83)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14087.10 Da        Isoelectric Point: 6.9566

>T196462 WP_207326524.1 NZ_CP071487:c1335279-1334914 [Glaesserella parasuis]
METEECLTFIETKIFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCKKIRWKLESNNKGKSGGVRVIYYVWSTKG
RIYLITMYSKSEKDNLNEKEKAIMRTVVAKLTGENNGKEII

Download         Length: 366 bp

>T196462 NZ_CP095132:c5047815-5046898 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCAGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11160.15 Da        Isoelectric Point: 10.3885

>AT196462 WP_021115782.1 NZ_CP071487:c1334933-1334637 [Glaesserella parasuis]
MEKKLFDRLIQGLEEMVAIEKGEIEVPPHRIHIHKIPNVKAIRTLHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPNLVPVLQNL

Download         Length: 297 bp

>AT196462 NZ_CP095132:c5048579-5047821 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References