Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 2189464..2190263 | Replicon | chromosome |
Accession | NZ_CP071439 | ||
Organism | Escherichia coli strain EcPNK004 |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | D3GWU5 |
Locus tag | J1F19_RS10395 | Protein ID | WP_000347272.1 |
Coordinates | 2189799..2190263 (+) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | S1EB98 |
Locus tag | J1F19_RS10390 | Protein ID | WP_001307405.1 |
Coordinates | 2189464..2189799 (+) | Length | 112 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J1F19_RS10375 | 2185249..2186019 | - | 771 | WP_207291711.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
J1F19_RS10380 | 2186035..2187369 | - | 1335 | WP_000599651.1 | galactarate/glucarate/glycerate transporter GarP | - |
J1F19_RS10385 | 2187744..2189315 | + | 1572 | WP_001273772.1 | galactarate dehydratase | - |
J1F19_RS10390 | 2189464..2189799 | + | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
J1F19_RS10395 | 2189799..2190263 | + | 465 | WP_000347272.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
J1F19_RS10400 | 2190318..2191127 | - | 810 | WP_000072171.1 | aga operon transcriptional regulator AgaR | - |
J1F19_RS10405 | 2191376..2192656 | + | 1281 | WP_000681955.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
J1F19_RS10410 | 2192679..2193152 | + | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
J1F19_RS10415 | 2193163..2193942 | + | 780 | WP_000406214.1 | PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC | - |
J1F19_RS10420 | 2193932..2194810 | + | 879 | WP_001295548.1 | PTS system mannose/fructose/sorbose family transporter subunit IID | - |
J1F19_RS10425 | 2194828..2195262 | + | 435 | WP_000948824.1 | PTS sugar transporter subunit IIA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2180102..2190263 | 10161 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17832.26 Da Isoelectric Point: 9.6924
>T196376 WP_000347272.1 NZ_CP071439:2189799-2190263 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH
Download Length: 465 bp
>T196376 NZ_CP095107:901668-901889 [Staphylococcus delphini]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGAGTGTTGTTATTGATTTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCATATAAAGGAGTGTAA
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGAGTGTTGTTATTGATTTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCATATAAAGGAGTGTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT196376 WP_001307405.1 NZ_CP071439:2189464-2189799 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT196376 NZ_CP095107:901368-901655 [Staphylococcus delphini]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAG
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGTTGCATCATGCATAAGATTGACGCAGGGCACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACGTTTCAAAAACTCATGAAAGATTAG
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAG
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGTTGCATCATGCATAAGATTGACGCAGGGCACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACGTTTCAAAAACTCATGAAAGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829KUD2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0XVC7 |